研究

柳津　茂慧
(ヤナイヅ　モトアキ)

所属
病態RNA制御学
職位
助教
学位
博士（薬科学）

研究キーワード

  • TREM2
  • アルツハイマー病
  • ミクログリア
  • 疾患RNA代謝
  • リピート伸長疾患

研究分野

  • ライフサイエンス

主な研究業績

  • Functional sQTLs regulating PTK2B exon 31 splicing uncover an RNA-dependent modulation of its kinase activity and cellular phenotype

    Masahide Kato, Ayaka Isazawa, Ai Ohki, Akari Fujita, Makoto Araki, Motoaki Yanaizu, Yoshihiro Kino

    Cell Commun Signal . 2026 Apr 2. doi: 10.1186/s12964-026-02835-x. Online ahead of print.

  • Transcriptional Activation of the TREM2 Gene by ZEB2 in a Zinc Finger-Dependent Manner

    Motoaki Yanaizu, Yuji Takata, Masahide Kato, Haruka Fujiwara, Yoshihiro Kino

    Genes (Basel) . 2025 Nov 3;16(11):1329. doi: 10.3390/genes16111329.

  • Transcriptome alterations underlying metabolic dysfunction and liver disease in myotonic dystrophy type 1

    Aono Fukumoto, Tomoki Yamanaka, Motoaki Yanaizu, Masayuki Nakamori, Manami Hama, Yoshiaki Yasumizu, Kana Shiotsu, Tsuyoshi Matsumura, Curtis A Nutter, Tomoya Kubota, Harutoshi Fujimura, Yoshihiro Kino, Maurice S Swanson, Kimiko Inoue, Masanori P Takahashi

    Hum Mol Genet . 2025 Oct 5;34(20):1718-1732. doi: 10.1093/hmg/ddaf124.

  • Comparative Analysis of MBNL1 Antibodies: Characterization of Recognition Sites and Detection of RNA Foci Colocalization

    Yoshitaka Aoki, Ai Ohki, Motoaki Yanaizu, Yoshihiro Kino

    Genes (Basel) . 2025 May 29;16(6):658. doi: 10.3390/genes16060658.

  • Identification of Splicing Regulatory Activity of ATXN1 and Its Associated Domains

    Ai Ohki, Masahide Kato, Yoshitaka Aoki, Arisa Kubokawa, Motoaki Yanaizu, Yoshihiro Kino

    Biomolecules . 2025 May 28;15(6):782. doi: 10.3390/biom15060782.

  • CUG repeat RNA-dependent proteasomal degradation of MBNL1 in a cellular model of myotonic dystrophy type 1

    Yoshitaka Aoki, Motoaki Yanaizu, Ai Ohki, Kai Nishimiya, Yoshihiro Kino

    Biochem Biophys Res Commun . 2024 Nov 12:733:150729. doi: 10.1016/j.bbrc.2024.150729. Epub 2024 Sep 21.

  • Translational regulation and protein-coding capacity of the 5' untranslated region of human TREM2

    Motoaki Yanaizu, Haruka Adachi, Makoto Araki, Kenji Kontani, Yoshihiro Kino

    Commun Biol . 2023 Jun 8;6(1):616. doi: 10.1038/s42003-023-04998-6.

  • Alzheimer's Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins

    Riho Komuro, Yuka Honda, Motoaki Yanaizu, Masami Nagahama, Yoshihiro Kino

    Cells . 2023 Feb 13;12(4):602. doi: 10.3390/cells12040602.

  • CELF2 regulates the species-specific alternative splicing of TREM2

    Motoaki Yanaizu, Chika Washizu, Nobuyuki Nukina, Jun-Ichi Satoh, Yoshihiro Kino

    Sci Rep . 2020 Oct 22;10(1):17995. doi: 10.1038/s41598-020-75057-x.

  • Small nuclear RNA-mediated modulation of splicing reveals a therapeutic strategy for a TREM2 mutation and its post-Transcriptional regulation

    Motoaki Yanaizu, Kenji Sakai, Youhei Tosaki, Yoshihiro Kino, Jun-Ichi Satoh

    Sci Rep . 2018 May 2;8(1):6937. doi: 10.1038/s41598-018-25204-2.

所属学協会

  • 日本薬学会
  • 日本分子生物学会
  • 日本RNA学会

研究者情報の詳細は
researchmap をご覧ください。

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