准教授：横屋　正志（ヨコヤ　マサシ）

薬化学

千葉大学大学院薬学研究科修士課程（2001年3月）

博士（薬学）　（明治薬科大学：2011年）

有機化学I、精密合成化学、薬の発見・発明、薬の科学実習I

有機合成化学

生物活性アルカロイドの合成学

日本薬学会、有機合成化学協会

Chemistry of renieramycins. Part 12: An improved total synthesis of (±)-renieramycin G. Tetrahedron., 68, 4166-4181 (2012).

Chemistry of renieramycins. Part 13: Isolation and structure of stabilized renieramycin type derivatives, renieramycins W-Y, from Philippine blue sponge Xestospongia sp., pretreated with potassium cyanide. Tetrahedron., 68, 7422-7428 (2012).

Preparation of Tricyclic Lactam Model Compounds of Renieramycin and Saframycin Anticancer Natural Products from Common Intermediate, Chem. Pharm. Bull., 61, 853-869 (2013).

Isolation, structure characterization, and synthesis of stabilized 1,2,3,4-tetrahydroisoquinoline marine natural product from potassium cyanide pretreated Thai tunicate, Ecteinascidia Thurstoni. Kimura S., Pangkruang W., Yokoya M., Honda A., Puthongking P., Suwanborirux K., Saito N., Heterocycles, 88, 363-375 (2014).

Preparation of renieramycin left-half model compound. Nakai K., Kubo K., Yokoya M., Saito N., Tetrahedron, 70, 6529-6545 (2014).

Synthetic Studies on Saframycin Anibiotics: An Improved Synthesis of Tricyclic Lactam Intermediate and Construction of the Core Ring System of Saframycin A. Kimura S., Kawai S., Azuma M., Umehara Y., Koizumi Y., Yokoya M., Saito N., Heterocycles, 90, 327-343 (2015).

Chemistry of Renieramycins. Part 14. Total Synthesis of Renieramycin I and Practical Synthesis of Cribrostatin 4 (Renieramycin H) Yokoya M., Kobayashi K., Sato M., Saito N., Marine Drugs, 13, 4915-4933 (2015).

抗腫瘍活性レニエラマイシン海洋天然物の化学的研究 横屋正志、齋藤直樹、有機合成化学協会誌、73、pp. 723-736 (2015).

Synthesis and Absolute Configuration of Acanthodendrilline, a New Cytotoxic Bromotyrosine Alkaloid from the Thai Marine Sponge Acanthodendrilla sp. Sirimangkalakitti N., Yokoya M., Chamni S., Chanvorachote P., Plubrukrn A., Saito N., Suwanborirux K., Chem. Pharm. Bull., 64, 258-262 (2016).

Stereoselective Total Synthesis of (－)-Renieramycin T Yokoya M., Toyoshima R., Suzuki T., Le V. H., Williams R. M., Saito N., J. Org. Chem., 81, 4039-4047 (2016).