研究

研究室

准教授:若林 朋子(ワカバヤシ トモコ)

役職名

准教授

研究室

病態生理学研究室

最終学歴

東京大学大学院薬学系研究科博士後期課程(2004年3月)

学位

博士(薬学)

専門分野

神経病理学

研究課題

神経変性疾患の病態形成機構の研究

所属学会

日本認知症学会、日本薬学会、Society for Neusocience

学会活動

日本認知症学会代議員

社会活動

Review editor of Frontiers in Molecular Neuroscience

研究業績1

Sano T, Ochiai T, Nagayama T, Nakamura A, Kubota N, Kadowaki T, Wakabayashi T*, Iwatsubo T*. Genetic reduction of insulin signaling mitigates amyloid-β deposition by promoting expression of extracellular matrix proteins in the brain. J Neurosci 43:7226-7241, 2023

研究業績2

Ochiai T, Sano T, Nagayama T, Kubota N, Kadowaki T, Wakabayashi T*, Iwatsubo T*. Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease. Neurobiol Dis 159:105510, 2021

研究業績3

Ochiai T, Nagayama T, Matsui K, Amano K, Sano T, Wakabayashi T*, Iwatsubo T*. Tauroursodeoxycholic acid attenuates diet-induced and age-related peripheral endoplasmic reticulum stress and cerebral amyloid pathology in a mouse model of Alzheimer’s disease. J Prev Alzheimer Dis 8:483-494, 2021

研究業績4

Wakabayashi T. Transmembrane collagens in neuromuscular development and disorders. Front Mol Neurosci 13:635375, 2021

研究業績5

Munezane H#, Oizumi H#, Wakabayashi T#*, Nishio S, Hirasawa T, Sato T, Harada A, Yoshida T, Eguchi T, Yamanashi Y, Hashimoto T, Iwatsubo T*. Roles of collagen XXV and its putative receptors PTPσ/δ in intramuscular motor innervation and congenital cranial dysinnervation disorder. Cell Rep 29:4362-4376, 2019

研究業績6

Wakabayashi T, Yamaguchi K, Matsui K, Sano T, Kubota T, Hashimoto T, Mano A, Yamada K, Matsuo Y, Kubota N, Kadowaki T, Iwatsubo T. Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer's disease. Mol Neurodegener 14:15, 2019

研究業績7

Tanaka T#, Wakabayashi T#, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T. CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. J Neurosci 34:1370-1379, 2014

研究業績8

Wakabayashi T, Craessaerts K, Bammens L, Bentahir M, Borgions F, Herdewijn P, Staes A, Timmerman E, Vandekerckhove J, Rubinstein E, Boucheix C, Gevaert K, De Strooper B. Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nat Cell Biol 11:1340-1346, 2009

研究業績9

Wakabayashi T, De Strooper B. Presenilins: members of the γ-secretase quartets, but part-time soloists too. Physiology 23:194-204, 2008

研究業績10

Hashimoto T#, Wakabayashi T#, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DMA, Iwatsubo T. CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. EMBO J 21:1524-1534, 2002