研究

研究室

教授:蒲生 修治(ガモウ シュウジ)

研究室

病態生理学

最終学歴

明治薬科大学大学院薬学研究科修士課程(1995年3月)

学位

博士(薬学)(明治薬科大学:2001年)

講義科目

病態生理学

専門分野

生理学、神経薬理学

研究課題

神経変性疾患の発症機序の解明と予防・治療法の開発

所属学会

日本薬学会、日本薬理学会、日本脂質栄養学会

学会活動

日本脂質栄養学会評議員、日本薬理学会学術評議員、日本薬理学会薬理学エデュケーター

学内委員

研究倫理委員会、実務実習委員会、ハラスメント防止委員会、OSCE実施委員会

研究業績1

Tanaka-Totoribe N, Hidaka M, Gamoh S, Yokota A, Nakamura N, Kuwabara M, Tsunezumi J, Yamamoto R. Effects of M-1, a major metabolite of sarpogrelate, on 5-HT-induced constriction of isolated human internal thoracic artery. Biol. Pharm. Bull. 43: 1979-1982, 2020.

研究業績2

Gamoh S, Shiba T, DiPette DJ, Yamamoto R. Differences in the response to periarterial nerve stimulation or exogenous noradrenaline infusion in the mesenteric vascular bed with the intestinal tract harvested from commonly used rat models of hypertension. Clin. Exp. Pharmacol. Physiol. 46: 427-434, 2019.

研究業績3

Shiba T, Yokota A, Gamoh S, Tanaka-Totoribe N, Kuwabara M, Nakamura E, Hayase T, Nakamura K, Yamamoto R. Diabetes Mellitus Induces Hyperreactivity of 5-Hydroxytryptamine (5-HT)-Induced Constriction in Human Internal Thoracic Artery and Is Associated with Increase in the Membrane Protein Level of 5-HT 2A Receptor. Biol. Pharm. Bull. 41: 820-823, 2018.

研究業績4

Yokota A, Gamoh S, Tanaka-Totoribe N, Shiba T, Kuwabara M, Nakamura E, Hayase T, Hisa H, Nakamura K, Yamamoto R. Angiotensin II, as well as 5-hydroxytriptamine, is a potent vasospasm inducer of saphenous vein graft for coronary artery bypass grafting in patients with diabetes mellitus. Biochem. Biophys. Rep. 6: 82-87, 2016.

研究業績5

Gamoh S, Kanai T, Tanaka-Totoribe N, Ohkura M, Kuwabara M, Nakamura E, Yokota A, Yamasaki T, Watanabe A, Hayashi M, Fujimoto S, Yamamoto R. Water-soluble jack-knife prawn extract inhibits 5-hydroxytryptamine-induced vasoconstriction and platelet aggregation in humans. Food Funct. 6: 444-449, 2015.

研究業績6

Gamoh S, Hisa H, Yamamoto R. 5-hydroxytryptamine receptors as targets for drug therapies of vascular-related diseases. Biol. Pharm. Bull. 36:1410-1415, 2013.

研究業績7

Kanai T, Kuwabara M, Tanaka-Totoribe N, Nakamura E, Matsuo Y, Gamoh S, Suzuki A, Asada Y, Hisa H, Yamamoto R. Insulin induces internalization of the plasma membrane 5-hydroxytryptamine2A (5-HT2A) receptor in the isolated human endothelium-denuded saphenous vein via the phosphatidylinositol 3-kinase pathway. J. Pharmacol. Sci. 118: 178-185, 2012

研究業績8

Gamoh S, Hashimoto M, Yanagimoto K, Katakura M, Haque MA, Shido O. Krill-derived phospholipids rich in n-3 fatty acid improve spatial memory in adult rats. J. Agri. Sci. 3: 3-12, 2011.

研究業績9

Hashimoto M, Tozawa R, Katakura M, Shahdat H, Haque AM, Tanabe Y, Gamoh S, Shido O. Protective effects of prescription n-3 fatty acids against impairment of spatial cognitive learning ability in amyloid β-infused rats. Food Funct. 2: 386-394, 2011.

研究業績10

Matsuo Y, Kuwabara M, Tanaka-Totoribe N, Kanai T, Nakamura E, Gamoh S, Suzuki A, Asada Y, Hisa H, Yamamoto R. The defective protein level of myosin light chain phosphatase (MLCP) in the isolated saphenous vein, as a vascular conduit in coronary artery bypass grafting (CABG), harvested from patients with diabetes mellitus (DM). Biochem. Biophys. Res. Commun. 412: 323-327, 2011.