研究

研究室

助教:大類 彩(オオルイ サヤカ)

研究室

薬品製造化学

最終学歴

筑波大学人間総合科学研究科生命システム医学専攻 (2019年3月)

学位

博士(医学) (2019年3月)

講義科目

薬の科学実習Ⅰ、薬の発見・発明、薬科学総合演習・実習

専門分野

有機化学、創薬化学

所属学会

日本薬学会、有機合成化学協会

研究業績1

Hiroshi Nagase, Naoshi Yamamoto, Masahiro Yata, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Daisuke Kuroda, Yurie Watanabe, Hiroaki Gouda, Masashi Yanagisawa.
“Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and their Pharmacologies”
J. Med. Chem. 2017, 60, 1018-1040. 参考情報

研究業績2

Naoshi Yamamotoa, Sayaka Ohruia, Takahiro Okada, Masahiro Yata, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase. aBoth authors have equally contributed.
“Essential structure of orexin 1 receptor antagonist YNT-707: Part I Role of the 4,5-epoxy ring for binding with orexin 1 receptor”
Bioorg. Med. Chem. Lett. 2017, 27, 4176-4179. 参考情報

研究業績3

Sayaka Ohrui, Naoshi Yamamoto, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, YokoIrukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase.
“Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity”
Bioorg. Med. Chem. Lett. 2018, 28, 774-777. 参考情報

研究業績4

Naoshi Yamamoto, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yasuhiro Ogawaa, Yukiko Ishikawaa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase.
“Essential structure of orexin 1 receptor antagonist YNT-707, Part III: Role of the 14-hydroxy and 3-methoxy groups in the YNT-707 derivatives without 4,5-eopxy ring on orexin 1 receptor antagonistic activity.” aBoth authors have equally contributed.
Bioorg. Med. Chem. 2019, 27, 1747-1758. 参考情報

研究業績5

Sayaka Ohrui, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Masashi Yanagisawa, Hiroshi Nagase.
”Design and Synthesis of Novel Orexin Antagonists via Structural Simplification of the Morphinan Skeleton”
Heterocycles, 2021, 103, 929-951. 参考情報

研究助成

日本学術振興会 科学研究費助成事業 (2020-2022年度) (若手研究)
モルヒナン化合物のオレキシン1受容体結合時における必須構造の解明