研究

大類　彩
(オオルイ　サヤカ)

所属
薬品製造化学
職位
助教
学位
博士（医学）

研究キーワード

  • 反応開発研究
  • 医薬品探索研究

研究分野

  • 有機合成化学
  • 有機金属化学
  • 創薬化学

主な研究業績

  • Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies

    Nagase H, Yamamoto N, Yata M, Ohrui S, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Hirayama S, Kuroda D, Watanabe Y, Gouda H, Yanagisawa M.

    J. Med. Chem. 60, 1018-1040 (2017).

  • Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.

    Yamamoto N, Ohrui S, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H.

    Bioorg. Med. Chem. Lett. 27, 4176-4179 (2017).

  • Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity.

    Ohrui S, Yamamoto N, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H.

    Bioorg. Med. Chem. Lett. 28, 774-777 (2018).

  • Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.

    Yamamoto N, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H.

    Bioorg. Med. Chem. 27, 1747-1758 (2019).

  • Design and Synthesis of Novel Orexin Antagonists via Structural Simplification of the Morphinan Skeleton

    Ohrui S, Irukayama-Tomobe Y, Ishikawa Y, Yanagisawa M, Nagase H.

    Heterocycles, 103, 929-951 (2021).

  • Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton.

    Maeda K, Ohrui S, Tokuda A, Nagumo Y, Yamamoto N, Tanimura R, Saitoh T, Kutsumura N, Nagase H.

    Org. Lett. 25, 3407-3411 (2023).

  • Synthesis of N-(acyloxy)-N-alkynylamides via generation of "C2" from hypervalent alkynyliodane and a weak base.

    Kagami K, Liang X, Ishibashi N, Ohrui S, Tayu M, Saito N.

    Chem. Commun. 59, 8274-8277 (2023).

  • A Photoredox/Sulfide Dual Catalysis System That Uses Sulfide Radical Cations to Promote Alkene Chlorotrifluoromethylation.

    Matsukuma K, Tayu M, Yashiro Y, Yamaguchi T, Ohrui S, Saito N.

    Chem. Pharm. Bull. 71, 695-700 (2023).

  • Photoredox Catalysis Using Methoxyarenes: Mechanistic Studies and Synthetic Applications

    Tayu M, Matsukuma K, Yamaguchi T, Noji M, Hayashi S, Ohrui S, Saito N.

    Bull. Chem. Soc. Jpn. 97, uoae138 (2024).

  • Photoredox/Sulfide Dual Catalysis for Modular Synthesis of Multi-substituted Furan Rings via Catalytic Indirect Reductive Quenching.

    Matsukuma K, Tayu M, Ogino T, Ohrui S, Noji M, Hayashi S, Saito N.

    Chem. Asian J. 20, e202401442 (2025).

  • A General Catalytic Sulfide-based Electron Donor–Acceptor Complex Platform for Decarboxylative Transformations of N-Hydroxyphthalimide Esters

    Matsukuma K, Tayu M, Noji M, Hayashi S, Ohrui S, Saito N.

    Adv. Synth. Catal. 367, e202500196 (2025).

  • Switchable Four- and Five-Component Reactions with Perfect Regioselectivity Promoted by Photoredox/Sulfide Dual-Catalytic Quenching for Access to Diverse Complex Imides

    Matsukuma K, Tayu M, Itai R, Imai K, Ohrui S, Saito N.

    J. Org. Chem. 90, 10454-10464 (2025).

  • Catalytic Synthesis of Azepinoindoles from Ynamides Containing Indolyl Moieties via Ruthenium–Vinylidene Species

    Tayu M, Watanabe R, Shinshima H, Hui Y, Ohrui S, Saito N.

    Chem. Pharm. Bull. 73, 732-737 (2025).

  • Aminoalkylation of Alkenes for Modular Pyrrolidine Synthesis via Electron Donor–Acceptor Complexes Generated from Alkenes and Amine-Tethered N-Hydroxyphthalimide Esters

    Tayu M, Matsukuma K, Ogino T, Ohrui S, Saito N.

    Chem. Pharm. Bull. 73, 738-744 (2025).

  • Synthesis of β3-Amino Acid Derivatives via the Regioselective Carbozincation of Ynamides and Subsequent Asymmetric Hydrogenation

    Ohrui S, Matsui S, Yoshida K, Oshida N, Tayu M, Saito N.

    Synthesis 2026 in press. (DOI: 10.1055/a-2779-0844)

  • De Novo Synthesis of Multisubstituted Pyrrolidines Based on a Programmed Radical [2 + 2 + 1] Annulation Strategy Using Sulfide-Based Electron Donor-Acceptor Catalysis

    Matsukuma K, Tayu M, Nakai K, Yamano M, Ohrui S, Yamaguchi T, Saito N.

    J. Org. Chem. 91, 4829-5262 (2026).

  • Association-gated multiphoton activation of inert haloarenes via sequential electron donor–acceptor assembly

    Matsukuma K, Tayu M, Muto K, Itai R, Noji M, Hayashi S, Ohrui S, Saito N.

    Nature Communications 17, 8914 (2026).

  • Nickel-catalyzed construction of seven-membered rings via [3 + 2 + 2] cycloaddition of cis-2,3-bis(trimethylsilyl)cyclopropanone and diynes

    Sato Y, Ohrui S, Tayu M, Yagi S, Kato M, Miki K, Nakai K, Yamano M, Saito N.

    ChemRxiv 2026 preprint（DOI: 10.26434/chemrxiv.15000398/v1）

  • From Sacrificial to Catalytic Photogenerated Reductant Formation: A Sulfide-Mediated Platform in Photoredox Catalysis

    Tayu M, Matsukuma K, Ohrui S, Saito N.

    Bull. Chem. Soc. Jpn. 99, uoag103 (2026).

  • 電子ドナー･アクセプター錯体を基盤とした光レドックス反応の設計と展開

    松隈 翔路, 田湯 正法, 大類 彩, 齋藤 望

    有機合成化学協会誌 84, 645–654 (2026).

所属学協会

  • 日本薬学会
  • 有機合成化学協会

社会・学術貢献活動

  • 次世代を担う有機化学シンポジウム世話人

    第24回次世代を担う有機化学シンポジウム実行委員（会場）
    2026年5月22日-5月23日

研究者情報の詳細は
researchmap をご覧ください。

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