助教：大類　彩（オオルイ　サヤカ）

薬品製造化学

筑波大学人間総合科学研究科生命システム医学専攻　（2019年3月）

博士（医学）　（2019年3月）

薬の科学実習Ⅰ、薬の発見・発明、薬科学総合演習・実習

有機化学、創薬化学

日本薬学会、有機合成化学協会

Hiroshi Nagase, Naoshi Yamamoto, Masahiro Yata, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Yasuhiro Ogawa, Shigeto Hirayama, Daisuke Kuroda, Yurie Watanabe, Hiroaki Gouda, Masashi Yanagisawa.
“Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and their Pharmacologies”
J. Med. Chem. 2017, 60, 1018-1040. 参考情報

Naoshi Yamamotoa, Sayaka Ohruia, Takahiro Okada, Masahiro Yata, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase. aBoth authors have equally contributed.
“Essential structure of orexin 1 receptor antagonist YNT-707: Part I Role of the 4,5-epoxy ring for binding with orexin 1 receptor”
Bioorg. Med. Chem. Lett. 2017, 27, 4176-4179. 参考情報

Sayaka Ohrui, Naoshi Yamamoto, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, YokoIrukayama-Tomobe, Yasuhiro Ogawa, Yukiko Ishikawa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase.
“Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity”
Bioorg. Med. Chem. Lett. 2018, 28, 774-777. 参考情報

Naoshi Yamamoto, Sayaka Ohrui, Takahiro Okada, Tsuyoshi Saitoh, Noriki Kutsumura, Yasuyuki Nagumo, Yoko Irukayama-Tomobe, Yasuhiro Ogawaa, Yukiko Ishikawaa, Yurie Watanabe, Daichi Hayakawa, Hiroaki Gouda, Masashi Yanagisawa, Hiroshi Nagase.
“Essential structure of orexin 1 receptor antagonist YNT-707, Part III: Role of the 14-hydroxy and 3-methoxy groups in the YNT-707 derivatives without 4,5-eopxy ring on orexin 1 receptor antagonistic activity.” aBoth authors have equally contributed.
Bioorg. Med. Chem. 2019, 27, 1747-1758. 参考情報

Sayaka Ohrui, Yoko Irukayama-Tomobe, Yukiko Ishikawa, Masashi Yanagisawa, Hiroshi Nagase.
”Design and Synthesis of Novel Orexin Antagonists via Structural Simplification of the Morphinan Skeleton”
Heterocycles, 2021, 103, 929-951. 参考情報

Kenta Maeda, Sayaka Ohrui, Akihisa Tokuda, Yasuyuki Nagumo, Naoshi Yamamoto, Ryuji Tanimura, Tsuyoshi Saitoh, Noriki Kutsumura, Hiroshi Nagase.
”Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton."
Org. lett. 2023, 25, 3407-3411. 参考情報

Kentaro Kagami, Xueying Liang, Nanako Ishibashi, Sayaka Ohrui, Masanori Tayu, Nozomi Saito.
”"Synthesis of N-(Acyloxy)-N-alkynylamides via Generation of “C2” from Hypervalent Alkynyliodane and Weak Base"
Chem. Commun. 2023, 59, 8274-8277. 参考情報

日本学術振興会 科学研究費助成事業 (2020-2022年度) (若手研究)

モルヒナン化合物のオレキシン1受容体結合時における必須構造の解明

日本学術振興会 科学研究費助成事業 (2023-2025年度) (若手研究)

新規オレキシン1受容体選択的リガンドの創製