研究

研究室

教授:森田 雄二(モリタ ユウジ)

研究室

感染制御学

最終学歴

岡山大学大学院自然科学研究科博士課程(2000年3月)

学位

博士(薬学)(岡山大学:2000年)

講義科目

微生物学Ⅰ、微生物学Ⅱ、生命科学実習Ⅳ、感染制御学(大学院)など

専門分野

微生物薬品学、分子微生物学

研究課題

抗菌薬耐性に関する研究~薬剤耐性菌の感染制御を目指して~

所属学会

日本薬学会、日本細菌学会、米国微生物学会(ASM)など

学会活動

日本細菌学会中部支部評議員(2013~2017)、第28回 微生物シンポジウム事務局(2016)、第50回 日本細菌学会中部支部事務局(2013)

社会活動

Frontiers in Microbiology Associate Editor、Frontiers in Microbiology Review Editor、Antibiotics Editor、Biological and Pharmaceutical Bulletin Editor、薬学雑誌編集者

研究業績1

Yuji Morita, Xian-Zhi Li
Antimicrobial resistance and drug efflux pumps in Vibrio and Legionella.
In “Efflux-mediated drug resistance in bacteria: mechanisms, regulations and clinical implications.”
edited by Xian-Zhi Li, Christopher A. Elkins, Helen I. Zgurskaya
Springer, 307-328, 2016.
doi: 10.1007/978-3-319-39658-3

研究業績2

Yuji Morita, Junko Tomida, Yoshiaki Kawamura
Resistance and response to anti-pseudomonas agents and biocides.
In “Pseudomonas-volume 7: new aspects of Pseudomonas biology”
edited by Juan-Luis Ramos, Johanna B. Goldberg, Alain Filloux
Springer, 173-187, 2015.

研究業績3

Yuji Morita, Junko Tomida, Yoshiaki Kawamura
Responses of Pseudomonas aeruginosa to antimicrobials.
Frontiers in Microbiology, 4: Article 422(1-8), 2014.
doi: 10.3389/fmicb.2013.00422.

研究業績4

Yuji Morita, Junko Tomida, Yoshiaki Kawamura
MexXY multidrug efflux system of Pseudomonas aeruginosa.
Frontiers in Microbiology, 3: Article 408 (1-13), 2012.
doi: 10.3389/fmicb.2012.00408.

研究業績5

Yuji Morita, Ken-ichi Nakashima, Kunihiko Nishino, Kenta Kotani, Junko Tomida, Makoto Inoue, Yoshiaki Kawamura.
Berberine is a novel type efflux inhibitor which attenuates the MexXY-mediated aminoglycoside resistance in Pseudomonas aeruginosa.
Frontiers in Microbiology, 7: Article 1223(1-10), 2016.
doi: 10.3389/fmicb.2016.01223.

研究業績6

Yuji Morita, Junko Tomida, Yoshiaki Kawamura
Efflux-mediated fluoroquinolone resistance in the multidrug-resistant Pseudomonas aeruginosa clinical isolate PA7: identification of a novel MexS variant involved in upregulation of the mexEF-oprN multidrug efflux operon.
Frontiers in Microbiology, 6: Article 8 (1-9), 2015.
doi: 10.3389/fmicb.2015.00008.

研究業績7

Yuji Morita, Junko Tomida, Yoshiaki Kawamura
Primary mechanisms mediating aminoglycoside resistance in the multidrug-resistant Pseudomonas aeruginosa clinical isolate PA7.
Microbiology, 158(4): 1071-1083, 2012.
doi: 10.1099/mic.0.054320-0.

研究業績8

Yuji Morita, Christie Gilmour, Devon Metcalf, Keith Poole
Translational control of the antibiotic inducibility of the PA5471 gene required for mexXY multidrug efflux gene expression in Pseudomonas aeruginosa.
Journal of Bacteriology, 191(15): 4966-4975, 2009.
doi: 10.1128/JB.00073-09.

研究業績9

Yuji Morita, Lily Cao, Virginia C. Gould, Matthew B. Avison, Keith Poole
nalD encodes a second repressor of the mexAB-oprM multidrug efflux operon of Pseudomonas aeruginosa.
Journal of Bacteriology, 188(24): 8649-8654, 2006.
doi: 10.1128/JB.01342-06.

研究業績10

Yuji Morita, Mara L. Sobel, Keith Poole
Antibiotic inducibility of the MexXY multidrug efflux system of Pseudomonas aeruginosa: involvement of the antibiotic-inducible PA5471 gene product.
Journal of Bacteriology, 188(5): 1847-1855, 2006.
doi: 10.1128/JB.188.5.1847-1855.2006.

研究業績11

Ryo Kutsuna,Junko Tomida,Yuji Morita,Yoshiaki Kawamura
Paraclostridium bifermentans exacerbates pathosis in a mouse model of ulcerative colitis.
PLoS One, 13(5): e0197668, 2018.
doi: 10.1371/journal.pone.0197668.

研究業績12

Kenta Kotani, Mio Matsumura, Yuji Morita, Junko Tomida, Ryo Kutsuna, Kunihiko Nishino, Shuji Yasuike, Yoshiaki Kawamura
13-(2-Methylbenzyl) berberine is a more potent inhibitor of MexXY-dependent aminoglycoside resistance than berberine.
Antibiotics (Basel), 8(4):212, 2019
doi: 10.3390/antibiotics8040212.

研究業績13

Kei Ikarashi, Ryo Kutsuna, Junko Tomida, Yoshiaki Kawamura, Yuji Morita
Overexpression of the MexXY Multidrug Efflux System Correlates with Deficient Pyoverdine Production in Pseudomonas aeruginosa.
Antibiotics (Basel), 10(6):658, 2021.doi: 10.3390/antibiotics10060658.