研究

若林　朋子（ワカバヤシトモコ）

所属
病態生理学
職位
准教授
学位
博士（薬学）（2004年 東京大学）

研究キーワード

  • 神経変性疾患
  • アルツハイマー病

研究分野

  • 神経病理学
  • 病態生化学

主な研究業績

  • Genetic reduction of insulin signaling mitigates amyloid-β deposition by promoting expression of extracellular matrix proteins in the brain.

    Sano T, Ochiai T, Nagayama T, Nakamura A, Kubota N, Kadowaki T, Wakabayashi T*, Iwatsubo T*

    J Neurosci 43:7226-7241, 2023

  • Differential involvement of insulin receptor substrate (IRS)-1 and IRS-2 in brain insulin signaling is associated with the effects on amyloid pathology in a mouse model of Alzheimer's disease.

    Ochiai T, Sano T, Nagayama T, Kubota N, Kadowaki T, Wakabayashi T*, Iwatsubo T*

    Neurobiol Dis 159:105510, 2021

  • Tauroursodeoxycholic acid attenuates diet-induced and age-related peripheral endoplasmic reticulum stress and cerebral amyloid pathology in a mouse model of Alzheimer’s disease.

    Ochiai T, Nagayama T, Matsui K, Amano T, Sano T, Wakabayashi T*, Iwatsubo T*

    J Prev Alzheimer Dis 8:483-494, 2021

  • Transmembrane collagens in neuromuscular development and disorders.

    Wakabayashi T

    Front Mol Neurosci 13:635375, 2021

  • Roles of collagen XXV and its putative receptors PTPσ/δ in intramuscular motor innervation and congenital cranial dysinnervation disorder.

    Munezane H#, Oizumi H#, Wakabayashi T#*, Nishio S, Hirasawa T, Sato T, Harada A, Yoshida T, Eguchi T, Yamanashi Y, Hashimoto T, Iwatsubo T*

    Cell Rep 29:4362-4376, 2019

  • Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer's disease.

    Wakabayashi T, Yamaguchi K, Matsui K, Sano T, Kubota T, Hashimoto T, Mano A, Yamada K, Kubota N, Kadowaki T, Iwatsubo T

    Mol Neurodegener 14:15, 2019

  • Chronic optogenetic activation augments Aβ pathology in a mouse model of Alzheimer disease.

    Yamamoto K, Tanei Z, Hashimoto T, Wakabayashi T, Okuno H, Naka Y, Yizhar O, Fenno LE, Fukuyama M, Bito H, Cirrito JR, Holtzman DM, Deisseroth K, Iwatsubo T

    Cell Rep 11:859-865, 2015

  • CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development.

    Tanaka T#, Wakabayashi T#, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T

    J Neurosci 34:1370-1379, 2014

  • Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains.

    Wakabayashi T, Craessaerts K, Bammens L, Bentahir M, Borgions F, Herdewijn P, Staes A, Timmerman E, Vandekerckhove J, Rubinstein E, Boucheix C, Gevaert K, De Strooper B

    Nat Cell Biol 11:1340-1346, 2009

  • Presenilins: Members of the γ-secretase quartets, but part-time soloists too.

    Wakabayashi T, De Strooper B

    Physiology 23:194-204, 2008

  • CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV.

    Hashimoto T#, Wakabayashi T#, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DMA, Iwatsubo T

    EMBO J 21:1524-1534, 2002

所属学協会

  • 日本認知症学会
  • 日本薬学会
  • Society for Neuroscience
  • International Society for Molecular Neurodegeneration (ISMND)

社会・学術貢献活動

  • 日本認知症学会　代議員


研究者情報の詳細は
researchmap をご覧ください。

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