研究

大類　彩
(オオルイ　サヤカ)

所属
薬品製造化学
職位
助教
学位
博士（医学）

研究分野

  • 有機合成化学
  • 有機金属化学
  • 創薬化学

主な研究業績

  • Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies

    Nagase H, Yamamoto N, Yata M, Ohrui S, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ishikawa Y, Ogawa Y, Hirayama S, Kuroda D, Watanabe Y, Gouda H, Yanagisawa M.

    J. Med. Chem. 60, 1018-1040 (2017).

  • Essential structure of orexin 1 receptor antagonist YNT-707, Part I: Role of the 4,5-epoxy ring for binding with orexin 1 receptor.

    Yamamoto N, Ohrui S, Okada T, Yata M, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H.

    Bioorg. Med. Chem. Lett. 27, 4176-4179 (2017).

  • Essential structure of orexin 1 receptor antagonist YNT-707, Part II: Drastic effect of the 14-hydroxy group on the orexin 1 receptor antagonistic activity.

    Ohrui S, Yamamoto N, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H.

    Bioorg. Med. Chem. Lett. 28, 774-777 (2018).

  • Essential structure of orexin 1 receptor antagonist YNT-707, part III: Role of the 14-hydroxy and the 3-methoxy groups in antagonistic activity toward the orexin 1 receptor in YNT-707 derivatives lacking the 4,5-epoxy ring.

    Yamamoto N, Ohrui S, Okada T, Saitoh T, Kutsumura N, Nagumo Y, Irukayama-Tomobe Y, Ogawa Y, Ishikawa Y, Watanabe Y, Hayakawa D, Gouda H, Yanagisawa M, Nagase H.

    Bioorg. Med. Chem. 27, 1747-1758 (2019).

  • Design and Synthesis of Novel Orexin Antagonists via Structural Simplification of the Morphinan Skeleton

    Ohrui S, Irukayama-Tomobe Y, Ishikawa Y, Yanagisawa M, Nagase H.

    Heterocycles, 103, 929-951 (2021).

  • Unexpected Rearrangement Reactions of the 14-Aminonaltrexone Skeleton.

    Maeda K, Ohrui S, Tokuda A, Nagumo Y, Yamamoto N, Tanimura R, Saitoh T, Kutsumura N, Nagase H.

    Org. Lett. 25, 3407-3411 (2023).

  • Synthesis of N-(acyloxy)-N-alkynylamides via generation of "C2" from hypervalent alkynyliodane and a weak base.

    Kagami K, Liang X, Ishibashi N, Ohrui S, Tayu M, Saito N.

    Chem. Commun. 59, 8274-8277 (2023).

  • A Photoredox/Sulfide Dual Catalysis System That Uses Sulfide Radical Cations to Promote Alkene Chlorotrifluoromethylation.

    Matsukuma K, Tayu M, Yashiro Y, Yamaguchi T, Ohrui S, Saito N.

    Chem. Pharm. Bull. 71, 695-700 (2023).

  • Photoredox Catalysis Using Methoxyarenes: Mechanistic Studies and Synthetic Applications

    Tayu M, Matsukuma K, Yamaguchi T, Noji M, Hayashi S, Ohrui S, Saito N.

    Bull. Chem. Soc. Jpn. 97, uoae138 (2024).

  • Photoredox/Sulfide Dual Catalysis for Modular Synthesis of Multi-substituted Furan Rings via Catalytic Indirect Reductive Quenching.

    Matsukuma K, Tayu M, Ogino T, Ohrui S, Noji M, Hayashi S, Saito N.

    Chem. Asian J. 20, e202401442 (2025).

  • A General Catalytic Sulfide-based Electron Donor–Acceptor Complex Platform for Decarboxylative Transformations of N-Hydroxyphthalimide Esters

    Matsukuma K, Tayu M, Noji M, Hayashi S, Ohrui S, Saito N.

    Adv. Synth. Catal. 367, e202500196 (2025).

  • Switchable Four- and Five-Component Reactions with Perfect Regioselectivity Promoted by Photoredox/Sulfide Dual-Catalytic Quenching for Access to Diverse Complex Imides

    Matsukuma K, Tayu M, Itai R, Imai K, Ohrui S, Saito N.

    J. Org. Chem. 90, 10454-10464 (2025).

  • Catalytic Synthesis of Azepinoindoles from Ynamides Containing Indolyl Moieties via Ruthenium–Vinylidene Species

    Tayu M, Watanabe R, Shinshima H, Hui Y, Ohrui S, Saito N.

    Chem. Pharm. Bull. 73, 732-737 (2025).

  • Aminoalkylation of Alkenes for Modular Pyrrolidine Synthesis via Electron Donor–Acceptor Complexes Generated from Alkenes and Amine-Tethered N-Hydroxyphthalimide Esters

    Tayu M, Matsukuma K, Ogino T, Ohrui S, Saito N.

    Chem. Pharm. Bull. 73, 738-744 (2025).

  • Synthesis of β3-Amino Acid Derivatives via the Regioselective Carbozincation of Ynamides and Subsequent Asymmetric Hydrogenation

    Ohrui S, Matsui S, Yoshida K, Oshida N, Tayu M, Saito N.

    Synthesis 2026 in press. (DOI: 10.1055/a-2779-0844)

  • De Novo Synthesis of Multisubstituted Pyrrolidines Based on a Programmed Radical [2 + 2 + 1] Annulation Strategy Using Sulfide-Based Electron Donor-Acceptor Catalysis

    Matsukuma K, Tayu M, Nakai K, Yamano M, Ohrui S, Yamaguchi T, Saito N.

    J. Org. Chem. 2026 in press. (DOI: 10.1021/acs.joc.5c02978)

所属学協会

  • 日本薬学会
  • 有機合成化学協会

社会・学術貢献活動

  • 次世代を担う有機化学シンポジウム

    世話人

研究者情報の詳細は
researchmap をご覧ください。

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