研究

菱沼　滋（ヒシヌマシゲル）

所属
薬効学
職位
教授
学位
薬学博士

研究キーワード

  • 受容体、細胞内情報伝達

研究分野

  • 分子薬理学、分子細胞生物学

主な研究業績

  • Endothelin-1 increases Na+-K+-2Cl- cotransporter-1 expression in cultured astrocytes and in traumatic brain injury model: An involvement of HIF1α activation.

    Koyama Y, Hamada Y, Fukui Y, Hosogi N, Fujimoto R, Hishinuma S, Ogawa Y, Takahashi K, Izumi Y, Michinaga S.

    Glia. 2024 Dec;72(12):2231-2246. doi: 10.1002/glia.24609.

  • Roles of astrocytic sonic hedgehog production and its signal for regulation of the blood-brain barrier permeability.

    Michinaga S, Hishinuma S, Koyama Y.

    Vitam Horm. 2024;126:97-111. doi: 10.1016/bs.vh.2024.04.006.

  • Histamine H1 receptor-mediated JNK phosphorylation is regulated by Gq protein-dependent but arrestin-independent pathways.

    Michinaga S, Nagata A, Ogami R, Ogawa Y, Hishinuma S.

    Int J Mol Sci. 2024 Mar 17;25(6):3395. doi: 10.3390/ijms25063395.

  • Differential regulation of histamine H1 receptor-mediated ERK phosphorylation by Gq proteins and arrestins.

    Michinaga S, Nagata A, Ogami R, Ogawa Y, Hishinuma S.

    Biochem Pharmacol. 2023 Jul;213:115595. doi: 10.1016/j.bcp.2023.115595.

  • Roles of astrocytic endothelin ETB receptor in traumatic brain injury.

    Michinaga S, Hishinuma S, Koyama Y.

    Cells. 2023 Feb 24;12(5):719. doi: 10.3390/cells12050719.

  • Selective histamine H2 receptor agonists alleviate blood-brain barrier disruption by promoting the expression of vascular protective factors following traumatic brain injury in mice.

    Michinaga S, Sonoda K, Inazuki N, Ezaki M, Awane H, Shimizu K, Hishinuma S, Mizuguchi H.

    Biol Pharm Bull. 2021;44(11):1759-1766. doi: 10.1248/bpb.b21-00512.

  • Molecular determinants of the kinetic binding properties of antihistamines at the histamine H1 receptors.

    Akimoto H, Uesawa Y, Hishinuma S.

    Int J Mol Sci. 2021 Feb 27;22(5):2400. doi: 10.3390/ijms22052400.

  • Differential regulation of bilastine affinity for human histamine H1 receptors by Lys 179 and Lys 191 via its binding enthalpy and entropy.

    Akimoto H, Sugihara M, Hishinuma S.

    Int J Mol Sci. 2021 Feb 6;22(4):1655. doi: 10.3390/ijms22041655.

  • Roles of Lys191 and Lys179 in regulating thermodynamic binding forces of ligands to determine their binding affinity for human histamine H1 receptors.

    Kobayashi C, Tanaka A, Yasuda T, Hishinuma S.

    Biochem Pharmacol. 2020 Oct;180:114185. doi: 10.1016/j.bcp.2020.114185.

所属学協会

  • 日本薬学会、日本薬理学会、日本生化学会、日本ヒスタミン学会

研究者情報の詳細は
researchmap をご覧ください。

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