研究

紺谷　圏二
(コンタニ　ケンジ)

所属
生化学
職位
教授
学位
博士（理学）

研究キーワード

  • シグナル伝達
  • 細胞内物質輸送
  • Gタンパク質

研究分野

  • 生化学
  • 細胞生物学

主な研究業績

  • Quantifying small GTPase activation status using a novel fluorescence HPLC-based assay

    Araki M, Kasuya Y, Yoshimoto K, Katada T, Kontani K.

    J Biol Chem. 2025 Jun;301(6):108545. doi: 10.1016/j.jbc.2025.108545.

  • Calmodulin enhances mTORC1 signaling by preventing TSC2-Rheb binding

    Amemiya Y, Ioi Y, Araki M, Kontani K, Maki M, Shibata H, Takahara T.

    J Biol Chem. 2025 Feb;301(2):108122. doi: 10.1016/j.jbc.2024.108122.

  • Analysis of the Guanine Nucleotide-Bound State of KRAS by Ion-Pair Reversed-Phase High-Performance Liquid Chromatography

    Araki M, Kontani K.

    Methods Mol Biol. 2024;2797:227-236. doi: 10.1007/978-1-0716-3822-4_16.

  • Translational regulation and protein-coding capacity of the 5' untranslated region of human TREM2

    Yanaizu M, Adachi H, Araki M, Kontani K, Kino Y.

    Commun Biol. 2023 Jun 8;6(1):616. doi: 10.1038/s42003-023-04998-6.

  • Development of a versatile HPLC-based method to evaluate the activation status of small GTPases

    Araki M, Yoshimoto K, Ohta M, Katada T, Kontani K.

    J Biol Chem. 2021 Dec;297(6):101428. doi: 10.1016/j.jbc.2021.101428.

  • Regulation of lysosomal positioning via TMEM55B phosphorylation

    Araki M, Kontani K.

    J Biochem. 2021 Jul 3;169(5):507-509. doi: 10.1093/jb/mvab013.

  • Decreased conformational stability in the oncogenic N92I mutant of Ras-related C3 botulinum toxin substrate 1

    Toyama Y, Kontani K, Katada T, Shimada I.

    Sci Adv. 2019 Aug 7;5(8):eaax1595. doi: 10.1126/sciadv.aax1595.

  • Loss of the small GTPase Arl8b results in abnormal development of the roof plate in mouse embryos

    Hashimoto K, Yamaguchi Y, Kishi Y, Kikko Y, Takasaki K, Maeda Y, Matsumoto Y, Oka M, Miura M, Ohata S, Katada T, Kontani K.

    Genes Cells. 2019 Jun;24(6):436-448. doi: 10.1111/gtc.12687.

  • Conformational landscape alternations promote oncogenic activities of Ras-related C3 botulinum toxin substrate 1 as revealed by NMR

    Toyama Y, Kontani K, Katada T, Shimada I.

    Sci Adv. 2019 Mar 13;5(3):eaav8945. doi: 10.1126/sciadv.aav8945.

  • ADP-ribosylation factor-like 8b is required for the development of mouse models of systemic lupus erythematosus

    Saitoh SI, Saitoh YM, Kontani K, Sato K, Miyake K.

    Int Immunol. 2019 Mar 28;31(4):225-237. doi: 10.1093/intimm/dxy084.

  • GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism

    Shimizu H, Toma-Fukai S, Kontani K, Katada T, Shimizu T.

    Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9563-9568. doi: 10.1073/pnas.1804740115.

  • TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells

    Saitoh SI, Abe F, Kanno A, Tanimura N, Mori Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K, Miyake K.

    Nat Commun. 2017 Nov 17;8(1):1592. doi: 10.1038/s41467-017-01687-x.

  • Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos

    Oka M, Hashimoto K, Yamaguchi Y, Saitoh SI, Sugiura Y, Motoi Y, Honda K, Kikko Y, Ohata S, Suematsu M, Miura M, Miyake K, Katada T, Kontani K.

    J Cell Sci. 2017 Oct 15;130(20):3568-3577. doi: 10.1242/jcs.200519.

所属学協会

  • 日本生化学会
  • 日本薬学会
  • 日本細胞生物学会
  • 日本分子生物学会
  • 日本癌学会

研究者情報の詳細は
researchmap をご覧ください。

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