研究

紀　嘉浩（キノヨシヒロ）

所属
病態RNA制御学
職位
教授
学位
博士（学術）

研究キーワード

  • リピート伸長疾患
  • 認知症
  • スプライシング
  • RNA結合タンパク質
  • 遺伝子発現制御

主な研究業績

  • CUG repeat RNA-dependent proteasomal degradation of MBNL1 in a cellular model of myotonic dystrophy type 1

    Yoshitaka Aoki, Motoaki Yanaizu, Ai Ohki, Kai Nishimiya, Yoshihiro Kino

    Biochemical and Biophysical Research Communications, 733: 150729-150729, 2024

  • Translational regulation and protein-coding capacity of the 5' untranslated region of human TREM2

    Motoaki Yanaizu, Haruka Adachi, Makoto Araki, Kenji Kontani, Yoshihiro Kino

    Communications Biology, 6: 616-616, 2023

  • Alzheimer's Disease-Associated Alternative Splicing of CD33 Is Regulated by the HNRNPA Family Proteins

    Riho Komuro, Yuka Honda, Motoaki Yanaizu, Masami Nagahama, Yoshihiro Kino

    Cells, 12:602, 2023

  • CELF2 regulates the species-specific alternative splicing of TREM2

    Motoaki Yanaizu, Chika Washizu, Nobuyuki Nukina, Jun-Ichi Satoh, Yoshihiro Kino

    Scientific Reports, 10: 17995-17995, 2020

  • Small nuclear RNA-mediated modulation of splicing reveals a therapeutic strategy for a TREM2 mutation and its post-Transcriptional regulation

    Motoaki Yanaizu, Kenji Sakai, Youhei Tosaki, Yoshihiro Kino, Jun-Ichi Satoh

    Scientific Reports, 8: 6937, 2018

  • FUS/TLS acts as an aggregation-dependent modifier of polyglutamine disease model mice

    Yoshihiro Kino, Chika Washizu, Masaru Kurosawa, Mizuki Yamada, Hiroshi Doi, Toru Takumi, Hiroaki Adachi, Masahisa Katsuno, Gen Sobue, Geoffrey G. Hicks, Nobutaka Hattori, Tomomi Shimogori, Nobuyuki Nukina

    Scientific Reports, 6:35236, 2016

  • FUS/TLS deficiency causes behavioral and pathological abnormalities distinct from amyotrophic lateral sclerosis

    Yoshihiro Kino, Chika Washizu, Masaru Kurosawa, Mizuki Yamada, Haruko Miyazaki, Takumi Akagi, Tsutomu Hashikawa, Hiroshi Doi, Toru Takumi, Geoffrey G. Hicks, Nobutaka Hattori, Tomomi Shimogori, Nobuyuki Nukina

    Acta Neuropathologica Communications, 3:24, 2015

  • Nuclear localization of MBNL1: splicing-mediated autoregulation and repression of repeat-derived aberrant proteins

    Yoshihiro Kino, Chika Washizu, Masaru Kurosawa, Yoko Oma, Nobutaka Hattori, Shoichi Ishiura, Nobuyuki Nukina

    Human Molecular Genetics, 24: 740-756, 2015

所属学協会

  • 日本薬学会
  • 日本分子生物学会
  • 日本神経科学学会
  • 日本RNA学会

研究者情報の詳細は
researchmap をご覧ください。

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