研究

田湯　正法（タユマサノリ）

所属
薬品製造化学
職位
講師
学位
博士（薬科学）

研究分野

  • 有機光化学、有機硫黄化学、有機金属化学、複素環化学

主な研究業績

  • Active thionium species mediated functionalization at the 2α-position of indole derivatives

    K. Higuchi, M. Tayu, T. Kawasaki

    Chem. Commun. 47, 6728-6730 (2011)

  • Sulfoxide-TFAA and Nucleophile Combination as New Reagent for Aliphatic C-H Functionalization at Indole 2α-position

    M. Tayu, K. Higuchi, M. Inaba, T. Kawasaki

    Org. Biomol. Chem. 11, 496-502 (2013)

  • Thionium-Based One-Pot Construction of Homo-/Heterodimeric Pyrroloindoline from Tryptamine

    M. Tayu, K. Higuchi, T. Ishizaki, T. Kawasaki

    Org. Lett. 16, 3613-3615 (2014)

  • Hypervalent Iodine Mediated One-Pot C-H Functionalization at 2α- or 3α-Position of Indole Derivatives

    K. Higuchi, M. Inaba, A. Naganuma, T. Ishizaki, M. Tayu, T. Kawasaki

    Heterocycles 89, 2105-2121 (2014)

  • Asymmetric Total Synthesis of (-)-Leuconoxine via Chiral Phosphoric Acid-Catalyzed Desymmetrization of a Prochiral Diester

    K. Higuchi, S. Suzuki, R. Ueda, N. Oshima, E. Kobayashi, M. Tayu, T. Kawasaki

    Org. Lett. 17, 154-157 (2015)

  • DMSO/Tf2O-mediated cross-coupling of tryptamine with substituted aniline to access C3a-N1′-linked pyrroloindoline alkaloids

    M. Tayu, T. Ishizaki, K. Higuchi, T. Kawasaki

    Org. Biomol. Chem. 13, 3863-3865 (2015)

  • C2-Symmetric Chiral Sulfoxide-Mediated Intermolecular Interrupted Pummerer Reaction for Enantioselective Construction of C3a-Substituted Pyrroloindolines

    M. Tayu, Y. Suzuki, K. Higuchi, T. Kawasaki

    Synlett 27, 941-945 (2016)

  • Design and Synthesis of Non-peptide RGD Mimics for Evaluation of their Utility as Anti-platelet Agents

    K. Higuchi, H. Hikita, A. Murayama, D. Yuri, N. Kobayakawa, T. Takahashi, S. Kojima, H. Ueno, T. Hatakeyama, A. Kato, M. Tayu, E. Oyama, S. Sugiyama, K. Ishii, H. Takahashi, T. Kawasaki

    Chem. Pharm. Bull. 64, 1726-1738 (2016)

  • Direct C2-Functionalization of Indoles Triggered by the Generation of Iminium Species from Indole and Sulfonium Salt

    M. Tayu, K. Nomura, K. Kawachi, K. Higuchi, N. Saito, T. Kawasaki

    Chem. Eur. J. 23, 10925-10930 (2017)

  • Total Synthesis of (+)-Gliocladin C Based on One-Pot Construction of a 3a-(3-Indolyl)pyrroloindoline Skeleton by Sulfonium-Mediated Cross-Coupling of Tryptophan and Indole

    M. Tayu, Y. Hui, S. Takeda, K. Higuchi, N. Saito, T. Kawasaki

    Org. Lett. 19, 6582-6585 (2017)

  • A metal-free biaryl coupling reaction activated by a sulfonium salt

    K. Higuchi, T. Tago, Y. Kokubo, M. Ito, M. Tayu, S. Sugiyama, T. Kawasaki

    Org. Chem. Front. 5, 3219-3225 (2018)

  • Facile Construction of an α-(1-Cyclopentenyl)ketone Core by Ruthenium-Catalyzed Hydrative Cyclization of 1,6-Allenyne: Total Synthesis of (+)-Myomontanone

    K. Katagiri, H. Kodera, M. Tayu, N. Saito

    Chem. Lett. 48, 768-770 (2019)

  • Trifluoromethyl sulfoxides: New reagents for metal‐free C–H trifluoromethylthiolation

    D. Wang, C. G. Carlton, M. Tayu, J. J. W. McDouall, G. J. P. Perry, D. J. Procter

    Angew. Chem. Int. Ed. 59, 15918-15922 (2020)

  • A Catalytic Construction of Indoles via Formation of Ruthenium Vinylidene Species from N‐Arylynamides

    M. Tayu, R. Watanabe, S. Isogi, N. Saito

    Adv. Synth. Catal. 363, 1147-1151 (2021)

  • Modular synthesis of unsymmetrical [1]benzothieno[3,2-b][1]benzothiophene molecular semiconductors for organic transistors

    M. Tayu, A. Rahmanudin, G. J. P. Perry, R. Khan, D. J. Tate, R. Marcial-Hernandez, Y. Shen, I. Dierking, Y. Janpatompong, S. Aphichatpanichakul, A. Zamhuri, I. Vitorica-Yrzebal, M. Turner, D. J. Procter

    Chem. Sci. 13, 421-429 (2022)

  • Synthesis of N-(Acyloxy)-N-alkynylamides via Generation of “C2” from Hypervalent Alkynyliodane and Weak Base

    K. Kagami, X. Liang, N. Ishibashi, S. Ohrui, M. Tayu, N. Saito

    Chem. Commun. 59, 8274-8277 (2023)

  • A Photoredox/Sulfide Dual Catalysis System That Uses Sulfide Radical Cations to Promote Alkene Chlorotrifluoromethylation

    K. Matsukuma, M. Tayu, Y. Yashiro, T. Yamaguchi, S. Ohrui, N. Saito

    Chem. Pharm. Bull. 71, 695-670 (2023)

  • Photoredox catalysis using methoxyarenes: mechanistic studies and synthetic applications

    M. Tayu, K. Matsukuma, T. Yamaguchi, M. Noji, S. Hayashi, S. Ohrui, N. Saito

    Bull. Chem. Soc. Jpn. 97, uoae138 (2024).

  • Photoredox/Sulfide Dual Catalysis for Modular Synthesis of Multi-Substituted Furan Rings via Catalytic Indirect Reductive Quenching

    K. Matsukuma, M. Tayu, T. Ogino, S. Ohrui, M. Noji, S. Hayashi, N. Saito

    Chem. Asian J. 20, e202401442 (2025).

  • A General Catalytic Sulfide-based Electron Donor–Acceptor Complex Platform for Decarboxylative Transformations of N-Hydroxyphthalimide Esters

    K. Matsukuma, M. Tayu, M. Noji, S. Hayashi, S. Ohrui, N. Saito

    Adv. Synth. Catal. 367, e202500196 (2025).

所属学協会

  • 日本薬学会、有機合成化学協会、光化学協会、複合系の光機能研究会、有機電子移動化学研究会

受賞

2013年 明治薬科大学ハイテクリサーチセンター若手研究奨励賞
2024年 有機合成化学協会研究企画賞

研究者情報の詳細は
researchmap をご覧ください。

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