教授：菱沼　滋（ヒシヌマ　シゲル）

薬効学

明治薬科大学大学院薬学研究科博士課程（1988年3月）

薬学博士（明治薬科大学：1988年）

生命科学実習II（2年）、創薬科学入門演習（2年）、薬理学III（3年）、薬物治療学III（3年）、薬科学総合実習・演習II（3年）、生命創薬科学総合演習ゼミ（大学院・生命創薬科学専攻）、受容体薬理学特論（大学院・生命創薬科学専攻）、薬効薬理学特論（大学院・薬学専攻）

受容体薬理学・受容体分子生物学

受容体機能の生理的・病理的・薬理的変動機構の解明と創薬・薬物治療への応用

日本薬理学会、日本薬学会、日本生化学会、日本ヒスタミン学会

日本薬理学会学術評議員（1993-）、日本ヒスタミン学会幹事（2004-）、日本薬学会第128年会組織委員（2007-2008）、日本薬学会関東支部運営委員（2010-2011）、日本薬学会代議員（2021-2022）

国家試験・CBT対策委員会、学生実習委員会、学外実務実習委員会（保険薬局実習部門）、マルチメディア教育委員会、出版委員会、施設管理委員会、放射線管理委員会、情報教育研究センター運営委員会、環境安全推進委員会

埼玉県病院薬剤師会研修センター外部委員（2011-）、明治薬科大学同窓会（明薬会）理事（2002-2014）

日本薬理学会年会「ヒスタミンH1受容体の細胞内移行と薬物感受性変化」（大阪、2004）、千葉県明薬会研修会「受容体研究最前線－基礎と臨床－」（千葉、2004）、東京都女性薬剤師会「エイコサノイドの薬理学」（東京、2007）

Desensitization of depolarization-mediated contractile pathways does not necessarily regulate receptor-mediated excitation-contraction coupling in longitudinal smooth muscle of guinea-pig ileum. Shigeru Hishinuma and Masaru Shoji. Clin. Exp. Pharmacol. Physiol., 38, 233-238 (2011).

The affinity of histamine for Gq protein-coupled histamine H1-receptors is predominantly regulated by their internalization in human astrocytoma cells. Shigeru Hishinuma, Yuko Sato, Chizuru Akatsu and Masaru Shoji. J. Pharmacol. Sci., 119, 233-242 (2012).

Membrane depolarization-induced RhoA/Rho-associated kinase activation and sustained contraction of rat caudal arterial smooth muscle involves genistein-sensitive tyrosine phosphorylation. Mitsuo Mita, Hitoshi Tanaka, Hayato Yanagihara, Junichi Nakagawa, Shigeru Hishinuma, Cindy Sutherland, Michael P. Walsh and Masaru Shoji. J. Smooth Muscle Res., 49, 26-45 (2013).

Molecular determinants responsible for sedative and non-sedative properties of histamine H1 receptor antagonists. Yoshihiro Uesawa, Shigeru Hishinuma and Masaru Shoji. J. Pharmacol. Sci., 124, 160-168 (2014).

Differential thermodynamic driving force of first- and second-generation antihistamines to determine their binding affinity for human H1 receptors. Shigeru Hishinuma, Kenta Sugawara, Yoshihiro Uesawa, Hiroyuki Fukui and Masaru Shoji. Biochem. Pharmacol., 91, 231-241 (2014).

Differential regulation of plasma copeptin levels in patients with heart failure: A single-center prospective study. Natsuko Iwashita, Noriko Nara, Ryosuke Sato, Tomoyori Nakatogawa, Shunichi Kobayashi, Sayuri Zama, Mitsuo Mita, Shigeru Hishinuma and Masaru Shoji. Tohoku. J. Exp. Med., 239, 213-221 (2016).

C-terminal of human histamine H1 receptors regulates their agonist-induced clathrin-mediated internalization and G-protein signaling. Shigeru Hishinuma, Hiroki Nozawa, Chizuru Akatsu and Masaru Shoji. J. Neurochem., 139, 552-565 (2016).

Asp73-dependent and -independent regulation of the affinity of ligands for human histamine H1 receptors by Na+. Shigeru Hishinuma, Kiyoe Kosaka, Chizuru Akatsu, Yoshihiro Uesawa, Hiroyuki Fukui and Masaru Shoji. Biochem. Pharmacol., 128, 46-54 (2017).

Inhibition of Ectopic Arginine Vasopressin Production by Phenytoin in the Small Cell Lung Cancer Cell Line Lu-165. Takahiro Ohta, Mitsuo Mita, Shigeru Hishinuma, Reiko Ishii-Nozawa R, Kazuhisa Takahashi and Masaru Shoji. Front. Endocrinol., 8, 94 (doi: 10.3389/fendo.2017.00094) (2017).

Ca2+-dependent down-regulation of human histamine H1 receptors in Chinese hamster ovary cells. Shigeru Hishinuma, Hiroshi Komazaki, Hayato Tsukamoto, Hirokazu Hatahara, Hiroyuki Fukui and Masaru Shoji. J. Neurochem., 144, 68-80 (2018).

Differential regulation of thermodynamic binding forces of levocetirizine and (S)-cetirizine by Lys191 in human histamine H₁ receptors. Shigeru Hishinuma, Yuri Tamura, Chihiro Kobayashi, Chizuru Akatsu and Masaru Shoji. Int. J. Mol. Sci., 19, e4067 (doi: 10.3390/ijms19124067) (2018).

Nadir lymphocytopenia as a risk factor of bloodstream infection during molecular targeting pharmacotherapy in multiple myeloma. Yukihiro Shimizu, Hiroaki Inoue, Shigeru Hishinuma and Masaru Shoji. Int. J. Clin. Pharmacol. Ther., 57, 542-551 (2019).

Roles of Lys191 and Lys179 in regulating thermodynamic binding forces of ligands to determine their binding affinity for human histamine H1 receptors. Chihiro Kobayashi, Airi Tanaka, Tomomi Yasuda and Shigeru Hishinuma. Biochem. Pharmacol., 180, 114185 (2020).

Differential regulation of bilastine affinity for human histamine H1 receptors by Lys 179 and Lys 191 via Its binding enthalpy and entropy. Hayato Akimoto, Minoru Sugihara, Shigeru Hishinuma. Int. J. Mol. Sci., 22, 1655, (2021).

Molecular determinants of the kinetic binding properties of antihistamines at the histamine H1 receptors. Hayato Akimoto, Yoshihiro Uesawa, Shigeru Hishinuma. Int. J. Mol. Sci., 22, 2400 (2021).

Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice. Shotaro Michinaga, Kazuya Onishi, Kahori Shimizu, Hiroyuki Mizuguchi, Shigeru Hishinuma. Biol. Pharm. Bull., 44, 1759-1766 (2021).