研究

研究室

講師:飯田 克巳(イイダ カツミ)

研究室

基礎薬学部門/有機化学

最終学歴

明治薬科大学大学院薬学研究科博士課程(1990年3月)

学位

薬学博士(明治薬科大学: 1990年)

講義科目

化学演習、総合物理系薬学、地域医療コース特論

専門分野

天然物化学

研究課題

生合成研究

所属学会

日本薬学会

学内委員

体験学習委員会、国家試験対策委員会、環境管理委員会、FD委員会

研究業績1

Mechanism of the ring contraction process in vitamin B12 biosynthesis by the anaerobe Propionibacterium shermanii under aerobic conditions. FEBS J. 274, 3475-3481 (2007)

研究業績2

Metabolic pathways leading from amino acids to vitamin B12 in Propionibacterium shermanii, and the sources of the seven methyl carbons. FEBS J. 274, 5090-5095 (2007)

研究業績3

Efficient syntheses of benzyl and n-octyl [1,3-13C2]acetoacetates, and their application to syntheses of 13C-labelled pyrrole and 13C-labelled hymecromone. J. Label. Compd. Radiopharm. 51, 167-169 (2008)

研究業績4

Efficient Synthesis of 13C-Labelled Erythromycin Biosynthetic Intermediate. 1: S-2-Acetylaminoethyl (2R,3R,4R,5R)-3,5-Diacetoxy-2,4-dimethyl-4-([13C]methoxy)heptanethioate. J. Label. Compd. Radiopharm. 51, 213-217 (2008)

研究業績5

Efficient Synthesis of 13C-Labelled Erythromycin Biosynthetic Intermediates. 2: S-2-Acetylaminoethyl (2S,3S,4S,5R,6R,7R)-3,6,7-Trihydroxy-2,4,6- trimethyl[1-13C]nonan-5-olide and (2R,3S,4S,5R,6S,7R)-3,5,6,7-Tetrahydroxy- 2,4,6-trimethyl[1-13C]nonanethioate. J. Label. Compd. Radiopharm. 51, 218-225 (2008)

研究業績6

Carbon source dependence of the ratio of δ-aminolevulinic acid biosynthesis via the C5 and Shemin pathways in Euglena gacilis (Euglenophyceae). J. Phycol. 44, 292-298 (2008)

研究業績7

Quantitative evaluation of the biosynthetic pathways leading to δ-aminolevulinic acid from the Shemin precursor glycine via the C5 pathway in Arthrobacter hyalinus by analysis of 13C-labeled coproporphyrinogen III biosynthesized from [2-13C]glycine, [1-13C]acetate, and [2-13C]acetate using 13C NMR spectroscopy. J. Radioanal. Nucl. Chem. 295, 1819-1827 (2013)

研究業績8

Investigation of the biosynthesis of acetyl-CoA and oxaloacetic acid from pyruvic acid and the quantitative evaluation of incorporated 13C-labeled L-alanine in Arthrobacter hyalinus. J. Radioanal. Nucl. Chem. 301, 897-904 (2014)

研究業績9

Investigation of acetyl-CoA and oxaloacetic acid biosynthesis from D-alanine-derived pyruvic acid in Arthrobacter hyalinus. J. Radioanal. Nucl. Chem. 304, 889-895 (2015)

研究業績10

Study on quality assurance for drug safety -Investigation of the content of heavy metal impurities in magnesium oxide preparations-. Pharmacometrics 95, 1-7 (2018)