准教授：小川　泰弘（オガワ　ヤスヒロ）

薬効学

総合研究大学院大学生命科学研究科生理科学専攻博士課程　（2004年3月）

博士（理学）　（総合研究大学院大学：2004年）

薬理学I、薬の発見・発明、薬物治療学要論II、院・受容体薬理学特論、生命科学実習II

神経科学

中枢神経系グリア細胞の制御機構

日本神経化学会、 米国神経科学会 (Society for Neruoscience)、 日本薬学会

National Multiple Sclerosis Society Postdoctral fellowship award

施設管理委員会、組換えＤＮＡ委員会、動物実験委員会、薬品管理システム運営委員会、バイオハザード安全委員会、学内実習委員会、学生厚生委員会

2014年　ひらめき☆ときめきサイエンス　実施責任者　「光らせて拡大して神経細胞の形を観察しよう！」 2015年　ひらめき☆ときめきサイエンス　実施責任者　「ミクロからマクロまで脳をまるごと大調査！」 2017年　文京アカデミア分担（明治薬科大学側責任者）　「脳の中のミクロな宇宙」

2017年　第19回　応用薬理シンポジウム「新規疾患資料戦略を志向した薬理学の新たな展開」

Ogawa Y, Schafer DP, Horresh I, Bar V, Hales K, Yang Y, Susuki K, Peles E, Stankewich MC, Rasband MN. Spectrins and ankyrinB constitute a specialized paranodal cytoskeleton. J Neurosci. 26, 5230-9, 2006.

Yang Y, Ogawa Y, Hedstrom KL, Rasband MN. βIV spectrin is recruited to axon initial segments and nodes of Ranvier by ankyrinG. J Cell Biol. 176, 509-19, 2007.

Mo Z, Moore AR, Filipovic R, Ogawa Y, Ikenaka K, Antic SD, Zecevic N. Human cortical neurons originate from radial glia and neuron-restricted progenitors. J Neurosci. 27, 4132-45, 2007.

Hedstrom KL, Xu X, Ogawa Y, Frischknecht R, Seidenbecher CI, Shrager P, Rasband MN. Neurofascin assembles a specialized extracellular matrix at the axon initial segment. J Cell Biol. 178, 875-86, 2007.

Ogawa Y, Horresh I, Trimmer JS, Bredt DS, Peles E, Rasband MN. Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2. J Neurosci. 28, 5731-9, 2008.

Hedstrom KL, Ogawa Y, Rasband MN. AnkyrinG is required for maintenance of the axon initial segment and neuronal polarity. J Cell Biol. 183, 635-40, 2008.

Ogawa Y, Rasband MN. Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins. J Neurosci Res. 87, 3502-10, 2009.

Ogawa Y, Oses-Prieto J, Kim MY, Horresh I, Peles E, Burlingame AL, Trimmer JS, Meijer D, Rasband MN. ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. J Neurosci. 30, 1038-48, 2010.

Susuki K, Raphael AR, Ogawa Y, Stankewich MC, Peles E, Talbot WS, Rasband MN. Schwann cell spectrins modulate peripheral nerve myelination. Proc Natl Acad Sci USA. 108, 8009-8014, 2011.

Galiano MR, Jha S, Ho TS, Zhang C, Ogawa Y, Chang KJ, Stankewich MC, Mohler PJ, Rasband MN. A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly. Cell, 149, 1125-1139, 2012.

Ogawa Y, Tanaka M, Tanabe M, Suzuki T, Togawa T, Fukushige T, Kanekura T, Sakuraba H, Oishi K. Impaired neural differentiation of induced pluripotent stem cells generated from a mouse model of Sandhoff disease. PLoS ONE, 8, e55856, 2013

Susuki K, Chang KJ, Zollinger DR, Liu Y, Ogawa Y, Eshed-Eisenbach Y, Dours-Zimmermann MT, Oses-Prieto JA, Burlingame AL, Seidenbecher CI, Zimmermann DR, Oohashi T, Peles E, Rasband MN. Three mechanisms assemble central nervous system nodes of Ranvier. Neuron, 78, 469-82, 2013

Hirono M, Ogawa Y, Misono K, Zollinger DR, Trimmer JS, Rasband MN, Misonou H. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells. J Neurosci. 35, 7082-94, 2015

Ogawa Y, Sano T, Irisa M, Kodama T, Saito T, Furusawa E, Kaizu K, Yanagi Y, Tsukimura T, Togawa T, Yamanaka S, Itoh K, Sakuraba H, Oishi K. FcRγ-dependent immune activation initiates astrogliosis during the asymptomatic phase of Sandhoff disease model mice. Scientific Reports. 7:40518, 2017

Ogawa Y, Kaizu K, Yanagi Y, Takada S, Sakuraba H, Oishi K. Abnormal differentiation of Sandhoff disease model mouse-derived multipotent stem cells toward a neural lineage. PLoS One. 12. e0178978. 2017

Ogawa Y, Irisa M, Sano T, Yanagi Y, Furusawa E, Saito T, Yamanaka S, Itoh K, Sakuraba H, Oishi K. Improvement in dysmyelination by the inhibition of microglial activation in a mouse model of Sandhoff disease. Neuroreport. 29 (11): 962-967. 2018

Ogawa Y, Furusawa E, Saitoh T, Sugimoto H, Omori T, Shimizu S, Kondo H, Yamazaki M, Sakuraba H, Oishi K. Inhibition of astrocytic adenosine receptor A2A attenuates microglial activation in a mouse model of Sandhoff disease. Neurobiology of Disease. 118: 142-154. 2018

Ogawa Y, Sasanuma Y, Shitara S, Koshizuka A, Okada R, Sakuraba H, Oishi K. Abnormal organization during neurodevelopment in a mouse model of Sandhoff disease. Neuroscience Research. S0168-0102(19): 30120-8, 2019

Tsukimura T, Shiga T, Saito K, Ogawa Y, Sakuraba H, Togawa T. Does administration of hydroxychloroquine/amiodarone accelerate accumulation of globotriaosylceramide and globotriaosylsphingosine in Fabry mice?　Molecular Genetics and Metabolism Reports. 28: 100773, 2021