研究

研究室

学長:越前 宏俊(エチゼン ヒロトシ)

役職名

学長

最終学歴

北海道大学医学部(1978年3月)

学位

医学博士(東京大学:1986年)

講義科目

学部:薬学への招待

専門分野

臨床薬理学・消化器病学

研究課題

薬物応答性の個人差に関わる遺伝要因、薬物相互作用、薬物代謝学

所属学会

日本臨床薬理学会、日本薬学会、日本TDM学会、日本アプライドセラピューティクス学会

学会活動

日本臨床薬理学会・評議委員(2000-)・同理事(2008-2014)、同名誉会員(2019-現在)、同学会誌編集委員(2003-現在)・編集委員長(2009-2016)・海外研修制度委員(2006-現在)・用語委員(2006-2014)、日本小児科学会薬事委員(2000-2014)、日本TDM学会評議員(2008―2014)・同学会理事(2011-2014)・同学会監事(2014-現在)

学内委員

薬学科長・副学長(2006-2018)、研究倫理委員会 (委員長、2000-2018)、医療人GP委員会(委員長、2006-2008)、学生厚生委員会(委員長、2010-2011)

社会活動

厚生労働省・薬剤師国家試験委員 (2000-2005)・薬事・食品衛生審議会専門委員(2001-2018)・保険医療専門審査委員 (2001-2018)、同医道審議会薬剤師分科会委員(2009-2015)、(独)医薬品医療機器総合機構専門委員(2004-2015)、国立健康・栄養研究所所認定栄養情報担当者認定試験委員(2005-2014)、日本小児血液学会臨床研究審査検討委員(2004-2014),日本小児科学会薬事委員会専門委員(2004-2016)、Clin Pharmacokinet誌査読者(1989-現在)、公益財団法人MR認定センター教育研修委員(2011-2013)、薬学雑誌・Biochem Biopharm Bull (2015-2017)

依頼公演

The 14th International Symposium on Microsomal Drug Oxidation"Pharmacogenetics of warfarin elimination and its clinical implications", Sapporo, 2002, Pharmaceutical Sciences World Congress 2004 "Therapeutic Drug Monitoring: Variability in Drug Response", Kyoto, 2004, The 4th World Conference on Drug Absorption, Transport and Delivery,"Population differences in the contribution of genetic polymorphism of pharmacokinetics/pharmacodynamics toward drug response", Kanazawa, 2007, The 85th Annual Meeting of Japanese Pharmacology Society: Joint Symposium between Japanese Pharmacology Society and Japanese Clinical Pharmacology and Therapeutics, "Pharmacogenomic Approaches for anticipating and avoiding adverse drug reactions", Kyoto, 2012, The 15th IATDMCT meeting "TDM in Pharmacogenomic generation!, Kyoto, 2017.

受賞歴

日本薬物動態学会ベストポスター賞(共同発表者1991, 2001)、日本薬学会関東支部大会優秀研究発表賞(指導教員2005), 日本臨床薬理学会優秀演題ポスター賞(指導教員2005)、日本臨床薬理学会優秀演題賞(指導教員2007)、日本TDM学会優秀ポスター賞(2014,2015)

研究業績1

Hirai T, Kimura T, Echizen H.: Modeling and Simulation for Estimating the Influence of Renal Dysfunction on Hypouricemic Effect of Febuxostat in Hyperuricemic Patients due to Overproduction or Underexcretion of Uric Acid, Biol Pharm Bull, 39;1013-21, 2016.

研究業績2

Sako A. Yoshida S, Yoshioka Y, Echizen H; Comprehensive Attempts to Promulgate Patient-Controlled Analgesia (PCA) in Palliative Care: Fact-finding Study of Cancer Patients and Questionnaire Survey of Healthcare Professionals on Implementing PCA in Real-World Practice. Japanese Journal of Pharmaceutical Palliative Care and Sciences, 11:111-118, 2018.

研究業績3

Asada M, Nagata M, Mizuno T, Uchida T, Kurashima N, Takahashi H, Makita K, Arai H, Echizen H, Yasuhara M: Effects of cardiopulmonary bypass on the disposition of cefazolin in patients undergoing cardiothoracic surgery, Pharmacology Research & Perspectives, 2018:e00440.

研究業績4

Okumura S, Ishihara Y, Yoshino K, Echizen H.: Possible drug interaction between oxydocone and erythromycin: A case report and analyses of spontaneous reporting systems of advers drug reactions. Jpn J Clin Pharmacol Ther 49:205-208, 2018.

研究業績5

Nango D, Hirose Y, Goto M and Echizen H.: Analysis on the Association of the Administration of Different Glucocorticoids with the Development of Acute Pancreatitis Using US Food and Drug Administration Adverse Event Reporting System (FAERS). J Pharm Health Care Sci, 2019, 5.5.

研究業績6

Ohgushi1 A, Nakayama N, Namiki A, Nagashima A, Ogawa R, Akazawa M, Echizen H.:A retrospective evaluation of the impact of multi-disciplinary approach for improving the quality of anticoagulation therapy in ambulatory patients with non-valvular atrial fibrillation receiving warfarin、Yakugaku-Zasshi, 139;1177-1183, 2019.

研究業績7

Nakayama H, Suzuki M, Kato T, Echizen H., Vancomycin pharmacokinetics in patients with advanced cancer near end of life, Eur J Drug Metab Pharmacokinet, 44:837-843, 2019.

研究業績8

Okumura S, Ishihara Y, Echizen H: Detection of Signals of Convulsion-inducing Effect for Fluoroquinolone Antibiotics Alone and with Co-administration of Nonsteroidal Anti-inflammatory Drugs in Association with Aging Using Japanese Adverse Drug Event Reporting Database, Japanese J Clin Pharmacol Ther, 50:203-2012、2019.

研究業績9

Hirai T, Naganuma M, Shiga T, Echizen H, Itoh T, Hagiwara N. Serum digoxin concentrations and outcomes in patients with heart failure and atrial fibrillation: a single-center observational study Jpn. J. Clin. Pharmacol. Ther 51:57-64, 2020.

研究業績10

Takahashi M, Shibasaki M, Echizen H, Kushiyama A. Comparisons between dipeptidyl peptidase-4 inhibitors and other classes of hypoglycemic drugs using two distinct biomarkers of pancreatic beta-cell function: A meta-analysis. PLoS One. 2020 15(7):e0236603.