研究

研究室

准教授:泉川 桂一(イズミカワ ケイイチ)

役職名

准教授

研究室

生体分子学

最終学歴

東京農工大学大学院連合農学研究科 博士課程 生物工学専攻 (2008年9月)

学位

博士(農学)(東京農工大学:2008年)

講義科目

生命科学実習Ⅲ

専門分野

分子生物学、細胞生物学

研究課題

ノンコーディングRNAの成熟化プロセスの研究、リボソーム生合成プロセスの解明、ALS原因遺伝子産物TDP-43の核内機能解析

所属学会

日本分子生物学会、日本RNA学会、日本薬学会

社会活動

文部科学省科学技術専門家ネットワーク・専門調査員

依頼講演

JST主催 東京農工大学・新技術説明会(2014年、2017年)

研究業績1

Association of human DNA helicase RecQ5 beta with RNA polymerase II and its possible role in transcription.
Izumikawa K, Yanagida M, Hayano T, Tachikawa H, Komatsu W, Shimamoto A, Futami K, Furuichi Y, Shinkawa T, Yamauchi Y, Isobe T, Takahashi N, Biochemical journal, 413(3) 505-516, Aug, 2008

研究業績2

Identification of truncated forms of U1 snRNA reveals a novel RNA degradation pathway during snRNP biogenesis.
Ishikawa H, Nobe Y, Izumikawa K, Yoshikawa H, Miyazawa N, Terukina G, Kurokawa N, Taoka M, Yamauchi Y, Nakayama H, Isobe T, Takahashi N, Nucleic acids research, 42(4) 2708-2724, Feb, 2014

研究業績3

A mass spectrometry-based method for direct determination of pseudouridine in RNA.
Yamauchi Y, Nobe Y, Izumikawa K, Higo D, Yamagishi Y, Takahashi N, Nakayama H, Isobe T, Taoka M, Nucleic acids research, 44(6) e59, Apr, 2016

研究業績4

Chtop (Chromatin target of Prmt1) auto-regulates its expression level via intron retention and nonsense-mediated decay of its own mRNA.
Izumikawa K, Yoshikawa H, Ishikawa H, Nobe Y, Yamauchi Y, Philipsen S, Simpson RJ, Isobe T, Takahashi N, Nucleic acids research, 44(20) 9847-9859, Nov, 2016

研究業績5

TDP-43 stabilises the processing intermediates of mitochondrial transcripts.
Izumikawa K, Nobe Y, Yoshikawa H, Ishikawa H, Miura Y, Nakayama H, Nonaka T, Hasegawa H, Egawa N, Inoue H, Nishikawa N, Yamano K, Simpson RJ, Taoka M, Yamauchi Y, Isobe T, Takahashi N, Scientific reports, 7(1) 7709-7709, Aug, 2017

研究業績6

Modulating the expression of Chtop, a versatile regulator of gene-specific transcription and mRNA export.
Izumikawa K, Ishikawa H, Simpson RJ, Takahashi N, RNA biology, 15(7) 1-7, May, 2018

研究業績7

Landscape of the complete RNA chemical modifications in the human 80S ribosome.
Taoka M, Nobe Y, Yamaki Y, Sato K, Ishikawa H, Izumikawa K, Yamauchi Y, Hirota K, Nakayama H, Takahashi N, Isobe T, Nucleic acids research, 46(18) 9289-9298, Sep, 2018

研究業績8

TDP-43 regulates site-specific 2'-O-methylation of U1 and U2 snRNAs via controlling the Cajal body localization of a subset of C/D scaRNAs.
Izumikawa K, Nobe Y, Ishikawa H, Yamauchi Y, Taoka M, Sato K, Nakayama H, Simpson RJ, Isobe T, Takahashi N,
Nucleic acids research, 47(5) 2487-2505, Feb, 2019

研究業績9

LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA.
Izumikawa K, Ishikawa H, Yoshikawa H, Fujiyama S, Watanabe A, Aburatani H, Tachikawa H, Hayano T, Miura Y, Isobe T, Simpson RJ, Li L, Min J, Takahashi N, Nucleic acids research, 47(19) 10357-10372, Nov, 2019

研究業績10

TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2.
Egawa N, Izumi Y, Suzuki H, Tsuge I, Fujita K, Shimano H, Izumikawa K, Takahashi N, Tsukita K, Enami T, Nakamura M, Watanabe A, Naitoh M, Suzuki S, Seki T, Kobayashi K, Toda T, Kaji R, Takahashi R, Inoue H, Scientific reports, 12(1) 7988-7988, May 14, 2022