研究

研究室

助教:峰岸 元気(ミネギシ ゲンキ)

役職名

助教

研究室

薬剤学

最終学歴

千葉大学大学院医学薬学府先端医学薬学専攻 4年制博士課程(2022年3月)

学位

博士(薬学) (千葉大学:2022年)

専門分野

薬物代謝学

研究課題

薬物間相互作用評価モデルの構築、薬物動態関連遺伝子の発現制御機構および機能の解明

所属学会

日本薬学会、日本薬物動態学会

研究業績1

Yamasaki Y, Kobayashi K, Okuya F, Kajitani N, Kazuki K, Abe S, Takehara S, Ito S, Ogata S, Uemura T, Ohtsuki S, Minegishi G, Akita H, Chiba K, Oshimura M, Kazuki Y. Characterization of P-glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans. Drug Metab Dispos 46:1756-1766 (2018)

研究業績2

Minegishi G, Kazuki Y, Yamasaki Y, Okuya F, Akita H, Oshimura M, Kobayashi K. Comparison of the hepatic metabolism of triazolam in wild-type and Cyp3a-knockout mice for understanding CYP3A-mediated metabolism in CYP3A-humanized mice in vivo. Xenobiotica 49:1303-1310 (2019)、Yamasaki Y, Kobayashi K, Okuya F, Kajitani N, Kazuki K, Abe S, Takehara S, Ito S, Ogata S, Uemura T, Ohtsuki S, Minegishi G, Akita H, Chiba K, Oshimura M, Kazuki Y. Characterization of P-glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans. Drug Metab Dispos 46:1756-1766 (2018)

研究業績3

Kobayashi K, Kuze J, Abe S, Takehara S, Minegishi G, Igarashi K, Kitajima S, Kanno J, Yamamoto T, Oshimura M, Kazuki Y. CYP3A4 induction in the liver and intestine of PXR/CYP3A-humanized mice: approaches by mass spectrometry imaging and portal blood analysis. Mol Pharmacol 96:600-608 (2019)

研究業績4

Minegishi G, Kazuki Y, Nitta S, Miyajima A, Akita H, Kobayashi K. In vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanized mice. Xenobiotica 57: 764-770 (2021)