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研究業績：原著論文 2018~
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- Miyake T, Tsutsui H, Haraya K, Tachibana T, Morimoto K, Takehara S, Ayabe M, Kobayashi K, Kazuk Y. Predicting quantitatively P-glycoprotein mediated drug-drug interactions and intestinal absorption using humanized mice. Br J Pharmacol, 178: 4335-4351 (2021)
- Minegishi G, Kazuki Y, Nitta S, Miyajima A, Akita H, Kobayashi K*. In vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanized mice. Xenobiotica 57: 764-770 (2021)
- Ohta Y, Kazuki K, Abe A, Oshimura M, Kobayashi K, Kazuki Y. Development of Caco-2 cells expressing four CYPs via a mammalian artificial chromosome. BMC Biotechnol, 20: 44 (2020)
- Kobayashi K*, Kuze J, Abe S, Takehara S, Minegishi G, Igarashi K, Kitajima S, Kanno J, Yamamoto T, Oshimura M, Kazuki Y. CYP3A4 induction in the liver and intestine of PXR/CYP3A-humanized mice: approaches by mass spectrometry imaging and portal blood analysis. Mol Pharmacol 96:600-608 (2019)
- Yokobori K, Ikuko A, Chiba K, Akita H, Furihata T, Kobayashi K*. Indirect activation of constitutive androstane receptor in three-dimensionally cultured HepG2 cells. Biochem Pharmacol 168:26-37(2019)
- Kazuki Y, Kobayashi K, Hirabayashi M, Abe S, Kajitani N, Kazuki K, Takehara S, Takiguchi M, Satoh D, Kuze J, Sakuma T, Kaneko T, Mashimo T, Osamura M, Hashimoto M, Wakatsuki R, Hirashima R, Fujiwara R, Deguchi T, Kurihara A, Tsukazaki Y, Senda N, Yamamoto T, Scheer N, Oshimura M. Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism. Proc Natl Acad Sci USA 116:3072-3081 (2019)
- Minegishi G, Kazuki Y, Yamasaki Y, Okuya F, Akita H, Oshimura M, Kobayashi K*. Comparison of the hepatic metabolism of triazolam in wild-type and Cyp3a-knockout mice for understanding CYP3A-mediated metabolism in CYP3A-humanized mice in vivo. Xenobiotica 49:1303-1310 (2019)
- Yamasaki Y, Kobayashi K*, Okuya F, Kajitani N, Kazuki K, Abe S, Takehara S, Ito S, Ogata S, Uemura T, Ohtsuki S, Minegishi G, Akita H, Chiba K, Oshimura M, Kazuki Y. Characterization of P-glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans. Drug Metab Dispos 46:1756-1766 (2018)
- Yamasaki Y, Kobayashi K*, Chiba K. Effect of pregnenolone 16α-carbonitrile on the expression of P-glycoprotein in the intestine, brain and liver of mice. Biol Pharm Bull 41:972-977 (2018)
- Nitta S, Hashimoto M, Kazuki Y, Takehara S, Suzuki H, Oshimura M, Akita H, Chiba K, Kobayashi K*. Evaluation of 4β-hydroxycholesterol and 25-hydroxycholesterol as endogenous biomarkers of CYP3A4: study with CYP3A-humanized mice. AAPS J 20:61 (2018)
- Yamasaki Y, Kobayashi K*, Inaba A, Uehara D, Tojima H, Kakizaki S, Chiba K. Indirect activation of pregnane X receptor in the induction of hepatic CYP3A11 by high-dose rifampicin in mice. Xenobiotica 48:1098-1105 (2018)
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