助教：小池　伸（コイケ　シン）

分析化学

明治薬科大学大学院薬学研究科博士課程（後期）（2014年3月）

博士（薬学）（明治薬科大学：2014年）

1) 統合失調症の早期発見のためのバイオマーカー探索 2) 生体内ポリサルファイド(多硫化物)の生理的機能解析

日本薬学会 日本生化学会 日本神経精神薬理学会 日本生物学的精神医学会

Koike S, Ogasawara Y, Shibuya N, Kimura H, Ishii K. Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells. FEBS Lett. 587, 3548-3555 (2013) 参照情報

Kimura Y, Toyofuku Y, Koike S, Shibuya N, Nagahara N, Lefer D, Ogasawara Y, Kimura H. Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain. Sci Rep. 5, 14774 (2015) 参照情報

Koike S, Kayama T, Arai M, Horiuchi Y, Kobori A, Miyashita M, Itokawa M, Ogasawara Y. Characterization of modified proteins in plasma from a subtype of schizophrenia based on carbonyl stress: Protein carbonyl is a possible biomarker of psychiatric disorders. Biochem Biophys Res Commun. 467, 361-366 (2015) 参照情報

Koike S, Kayama T, Yamamoto S, Komine D, Tanaka R, Nishimoto S, Suzuki T, Kishida A, Ogasawara Y. Polysulfides protect SH-SY5Y cells from methylglyoxal-induced toxicity by suppressing protein carbonylation: A possible physiological scavenger for carbonyl stress in the brain. Neurotoxicology. 55, 13-19 (2016) 参照情報

Koike S, Tanaka Y, Matsuzaki T, Morishita Y, Ishibashi K. Aquaporin-11 (AQP11) Expression in the Mouse Brain. Int. J. Mol. Sci. 17, 861 (2016) 参照情報

Nishimoto S, Suzuki T, Koike S, Yuan B, Takagi N, Ogasawara Y. Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells. Toxicol Appl Pharmacol. 305, 161-168 (2016) 参照情報

Koike S, Ogasawara Y. Sulfur Atom in its Bound State Is a Unique Element Involved in Physiological Functions in Mammals. (Review) Molecules, 21, 1753 (2016) 参照情報

Koike S, Nishimoto S, Ogasawara Y. Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation. Redox Biol. 12, 530-539 (2017) 参照情報

Kimura Y, Koike S, Shibuya N, Lefer D, Ogasawara Y, Kimura H. 3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S. Sci Rep. 7, 10459 (2017) 参照情報

Koike S, Kawamura K, Kimura Y, Shibuya N, Kimura H, Ogasawara Y. Analysis of endogenous H2S and H2Sn in mouse brain by high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection. Free Radic. Biol. Med. 113, 355-362 (2017) 参照情報

Nagahara N, Koike S, Nirasawa T, Kimura H, Ogasawara Y.
Alternative pathway of H2S and polysulfides production from sulfurated catalytic-cysteine of reaction intermediates of 3-mercaptopyruvate sulfurtransferase. Biochem Biophys Res Commun. 496, 648-653 (2018) 参照情報

Koike S, Ando C, Usui Y, Kibune Y, Nishimoto S, Suzuki T, Ogasawara Y. Age-related alteration in the distribution of methylglyoxal and its metabolic enzymes in the mouse brain. Brain Res Bull. 144, 164-170 (2019) 参照情報