教育・研究

明治薬科大学教員総覧

助教:小池 伸(コイケ シン)

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研究室

分析化学

最終学歴

明治薬科大学大学院薬学研究科博士課程(後期)(2014年3月)

学位

博士(薬学)(明治薬科大学:2014年)

研究課題

1) 統合失調症の早期発見のためのバイオマーカー探索 2) 生体内ポリサルファイド(多硫化物)の生理的機能解析

所属学会

日本薬学会 日本生化学会 日本神経精神薬理学会 日本生物学的精神医学会

研究業績1

Koike S, Ogasawara Y, Shibuya N, Kimura H, Ishii K. Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells. FEBS Lett. 587, 3548-3555 (2013) 参照情報

研究業績2

Kimura Y, Toyofuku Y, Koike S, Shibuya N, Nagahara N, Lefer D, Ogasawara Y, Kimura H. Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain. Sci Rep. 5, 14774 (2015) 参照情報

研究業績3

Koike S, Kayama T, Arai M, Horiuchi Y, Kobori A, Miyashita M, Itokawa M, Ogasawara Y. Characterization of modified proteins in plasma from a subtype of schizophrenia based on carbonyl stress: Protein carbonyl is a possible biomarker of psychiatric disorders. Biochem Biophys Res Commun. 467, 361-366 (2015) 参照情報

研究業績4

Koike S, Kayama T, Yamamoto S, Komine D, Tanaka R, Nishimoto S, Suzuki T, Kishida A, Ogasawara Y. Polysulfides protect SH-SY5Y cells from methylglyoxal-induced toxicity by suppressing protein carbonylation: A possible physiological scavenger for carbonyl stress in the brain. Neurotoxicology. 55, 13-19 (2016) 参照情報

研究業績5

Koike S, Tanaka Y, Matsuzaki T, Morishita Y, Ishibashi K. Aquaporin-11 (AQP11) Expression in the Mouse Brain. Int. J. Mol. Sci. 17, 861 (2016) 参照情報

研究業績6

Nishimoto S, Suzuki T, Koike S, Yuan B, Takagi N, Ogasawara Y. Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells. Toxicol Appl Pharmacol. 305, 161-168 (2016) 参照情報

研究業績7

Koike S, Ogasawara Y. Sulfur Atom in its Bound State Is a Unique Element Involved in Physiological Functions in Mammals. (Review) Molecules, 21, 1753 (2016) 参照情報

研究業績8

Koike S, Nishimoto S, Ogasawara Y. Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation. Redox Biol. 12, 530-539 (2017) 参照情報

研究業績9

Kimura Y, Koike S, Shibuya N, Lefer D, Ogasawara Y, Kimura H. 3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S. Sci Rep. 7, 10459 (2017) 参照情報

研究業績10

Koike S, Kawamura K, Kimura Y, Shibuya N, Kimura H, Ogasawara Y. Analysis of endogenous H2S and H2Sn in mouse brain by high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection. Free Radic. Biol. Med. 113, 355-362 (2017) 参照情報

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