講師：小池 伸（コイケ シン）
| 研究室 | |
|---|---|
| 最終学歴 |
明治薬科大学大学院薬学研究科博士課程（後期）（2014年3月） |
| 学位 |
博士（薬学）（明治薬科大学：2014年） |
| 講義課目 |
薬の科学実習Ⅲ‐1、 院・薬学専攻・分析化学特論、院・生命創薬科学専攻・生体分析化学特論 |
| 研究課題 |
中枢神経系疾患に関与するカルボニル化タンパク質の生成及び除去機構の解明 |
| 所属学会 |
日本薬学会 日本生化学会 日本神経精神薬理学会 日本生物学的精神医学会 |
| 学内委員会 |
ハラスメント防止委員会 |
| 研究業績1 |
Koike S, Kayama T, Yamamoto S, et al. Polysulfides protect SH-SY5Y cells from methylglyoxal-induced toxicity by suppressing protein carbonylation: A possible physiological scavenger for carbonyl stress in the brain. Neurotoxicology 55 13-19 (2016) |
| 研究業績2 |
Koike S, Nishimoto S, Ogasawara Y. Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation. Redox Biol. 12, 530-539 (2017) |
| 研究業績3 |
Koike S, Kawamura K, Kimura Y, Shibuya N, Kimura H, Ogasawara Y. Analysis of endogenous H2S and H2Sn in mouse brain by high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection. Free Radic. Biol. Med. 113, 355-362 (2017) |
| 研究業績4 |
Nagahara N, Koike S, Nirasawa T, Kimura H, Ogasawara Y. Alternative pathway of H2S and polysulfides production from sulfurated catalytic-cysteine of reaction intermediates of 3-mercaptopyruvate sulfurtransferase. Biochem Biophys Res Commun. 496, 648-653 (2018) |
| 研究業績5 |
Koike S, Ando C, Usui Y, Kibune Y, Nishimoto S, Suzuki T, Ogasawara Y. Age-related alteration in the distribution of methylglyoxal and its metabolic enzymes in the mouse brain. Brain Res Bull. 144, 164-170 (2019) |
| 研究業績6 |
Sugiura K, Koike S, Suzuki T, Ogasawara Y. Oxidative Formation of Methylglyoxal in Glycerol Preparations during Storage. Biol Pharm Bull. 43(5) 879-883 (2020) |
| 研究業績7 |
Toriumi K, Berto S, Koike S, et al. Combined glyoxalase 1 dysfunction and vitamin B6 deficiency in a schizophrenia model system causes mitochondrial dysfunction in the prefrontal cortex. Redox Biol. 45 102057 (2021) |
| 研究業績8 |
Koike S, Toriumi K, Kasahara S, et al. Accumulation of Carbonyl Proteins in the Brain of Mouse Model for Methylglyoxal Detoxification Deficits. Antioxidants 10(4) (2021) |
| 研究業績9 |
Koike S, Tanaka Y, Morishita Y, Ishibashi K. Effects of osmolality on the expression of brain aquaporins in AQP11-null mice. Biochimie 188 2-6 (2021) |
| 研究業績10 |
Sugiura K*, Koike S*, Suzuki T, Ogasawara Y. (* equal contribution) Carbonylation of skin collagen induced by reaction with methylglyoxal. Biochem Biophys Res Commun. 562 100-104 (2021) |