研究

研究室

助教:宮嶋 篤志(ミヤジマ アツシ)

研究室

薬剤学

最終学歴

千葉大学大学院薬学研究院創薬生命科学専攻後期3年博士課程(2009年3月)

学位

博士(薬学) (千葉大学:2009年)

講義科目

薬剤基礎実習、臨床薬学基礎実習、事前実務実習(前期・後期)、薬剤学III、薬物動態解析学

専門分野

薬物動態学

研究課題

*新規製剤開発とその薬物動態評価(イベルメクチン全身浴法等)
*頭部冷却が抗がん剤の毛髪曝露に与える影響;抗癌剤性脱毛予防を目指して

所属学会

日本薬学会、日本薬物動態学会、日本医療薬学会、日本TDM学会

学会活動

疥癬診療ガイドライン(第4版)作成委員会 委員

研究業績1

Functional analysis of the GC box and its methylation in the regulation of CYP1A2 gene expression. Drug Metab. Pharmacokinet. 2009, 24: 269-276.

研究業績2

Striking species difference in the contribution of concentrative nucleoside transporter 2 to nucleoside uptake between mouse and rat hepatocytes. Antimicrob. Agents Chemother. 2010, 54: 3035-3038.

研究業績3

Identification of a new organic anion transporting polypeptide 1B3 mRNA isoform primarily expressed in human cancerous tissues and cells. Biochem. Biophys.Res.Commun. 2012, 418: 813-823.

研究業績4

簡易懸濁法の器具および手技がストロメクトール®錠の投与量に及ぼす影響. 医療薬学2012年, 38巻2号78-86頁.

研究業績5

Disruption of elastic lamellae in the aorta by D-penicillamine and its effect on vaso-regulation in rats. J. Toxicol. Sci. 2013, 38:707-717.

研究業績6

Disruption of elastic lamellae in aorta and dysfunction of vaso-regulation by rofecoxib in rats. J. Toxicol. Sci. 2013, 38:719-729.

研究業績7

Effects of postnatal dexamethasone treatment on mRNA expression profiles of genes related to alveolar development in an emphysema model in mice. J. Toxicol. Sci. 2014, 39: 665-670

研究業績8

経鼻チューブを使用した経管投与がストロメクトール®錠の投与量に及ぼす影響. 医療薬学 2014年, 40巻9号515-521頁.

研究業績9

Experimental study of pharmacokinetics of external, whole body bathing application of ivermectin. J. Dermatol. 2015, 42: 87-89.

研究業績10

Dysfunction of blood pressure regulation in hyperhomocyteinemia model in rats. J. Toxicol. Sci. 2015, 40: 211-221.

研究業績11

Effect of high fat intake on the pharmacokinetic profile of ivermectin in rabbits. Drug Metab. Pharmacokinet., 2015; 30: 253-256.

研究業績12

Effect of γ-cyclodextrin inclusion complex on the absorption of R-α-lipoic acid in rats. Int. J. Mol. Sci., 2015, 16: 10105-10120.

研究業績13

Mechanism for transport of ivermectin to the stratum corneum in rats. Drug Metab. Pharmacokinet.,30, 385-390 (2015).

研究業績14

Effects of rofecoxib on lipid oxidation in plasma and aortas of rats. Fund. Toxicol. Sci. 2015, 2: 155-159.

研究業績15

Serum concentrations of clarithromycin and rifampicin in pulmonary Mycobacterium avium complex disease: long-term changes due to drug interactions and their association with clinical outcomes. J. Pharm. Health Care Sci. 2015, DOI: 10.1186/s40780-015-0029-0.

研究業績16

Effect of high fat meal intake on the pharmacokinetic profile of ivermectin in Japanese patients with scabies. J. Dermatol., 2016, 43, 1030-1036.

研究業績17

Effects of all trans-retinoic acid on alveolar regeneration and its relationship to exposure in mice. Bio. Pharm. Bull, 2016, 39, 927-934.

研究業績18

Effect of tiopronin on excretion of homocysteine and its plasma exposure level in rats. Drug Metab Pharmacokinet., 31, 249-251 (2016).

研究業績19

Population differences in S-warfarin pharmacokinetics among African Americans, Asians and whites: their influence on pharmacogenetic dosing algorithms. Pharmacogenomics J., 2016 Aug 9. doi: 10.1038/tpj.2016.57.

研究業績20

Bioavailability of an R-alpha-lipoic acid/γ-cyclodextrin complex in healthy volunteers. Int. J. Mol. Sci., 2016, 17, E949 (2016).

研究業績21

Pharmacokinetics of ivermectin applied topically by whole-body bathing method in healthy volunteers. J. Dermatol.,44, 406-413 (2017).

研究業績22

Effects of Simvastatin on Alveolar Regeneration and Its Relationship to Exposure in Mice with Dexamethasone-Induced Emphysema. Biol Pharm Bull, 40, 155-160 (2017)