研究

研究室

助手:木村 真也(キムラ シンヤ)

研究室

薬化学

最終学歴

千葉大学大学院薬学研究科修士課程(2011年3月)

学位

修士(薬学)(千葉大学:2011年)

講義科目

薬の科学実習Ⅰ、薬科学総合演習・実習

専門分野

有機合成化学

研究課題

生物活性天然物の全合成と医薬化学研究

所属学会

日本薬学会、有機合成化学協会

研究業績1

Isolation, structure characterization, and synthesis of stabilized 1,2,3,4-tetrahydroisoquinoline marine natural product from potassium cyanide pretreated Thai tunicate, Ecteinascidia thurstoni, Shinya Kimura, Waree Pangkruang, Masashi Yokoya, Amane Honda, Ploenthip Puthongking, Khanit Suwanborirux, Naoki Saito, Heterocycles, 88, 363-375 (2014).

研究業績2

Synthetic studies on saframycin antibiotics: an improved, synthesis of tricyclic lactam intermediate and construction of the core ring system of saframycin A, Shinya Kimura, Shintaro Kawai, Masayuki Azuma, Yoshifumi Umehara, Yu-ichi Koizumi, Masashi Yokoya, Naoki Saito, Heterocycles, 90, 327-343 (2014).

研究業績3

Total synthesis of (±)-lycoposerramine-R, a novel skeletal type of Lycopodium alkaloid, Hiroaki Ishida, Shinya Kimura, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama, Tetrahedron, 71, 51-56 (2015). H. Ishida and S. Kimura contributed equally to this work.

研究業績4

The first asymmetric total synthesis of lycoposerramine-R, Hiroaki Ishida, Shinya Kimura, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama, Org. Biomol. Chem., 13, 7762-7771 (2015).

研究業績5

Semisynthesis and biological evaluation of prenylated resveratrol
derivatives as multi-targeted agents for Alzheimer’s disease, Thanchanok Puksasook, Shinya Kimura, Sarin Tadtong, Jutamas Jiaranaikulwanitch, Jaturong Pratuangdejkul, Worawan Kitphati, Khanit Suwanborirux, Naoki Saito, Veena Nukoolkarn, J. Nat. Med., 71, 665-682 (2017).

研究業績6

Preparation of chiral right-half models of antitumor bistetrahydroisoquinolinequinone natural products, Yuuki Senbonmatsu, Shinya Kimura, Megumi Akiba, Shingo Ando, Naoki Saito, Heterocycles, DOI: 10.3987/COM-18-S(T)88.

研究業績7

A stereocontrolled total synthesis of (±)-saframycin A, Shinya Kimura, Naoki Saito, Tetrahedron, 74, 4504-4514 (2018).

研究業績8

Construction of the pentacyclic core and formal total synthesis of (rac)-renieramycin T, Shinya Kimura, Naoki Saito, ChemistryOpen, 7, 764-771 (2018). Selected as a front cover picture.