キムラシンヤ｜明治薬科大学

研究キーワード

有機合成化学
超分子化学
天然物化学
創薬化学
ケミカルバイオロジー

研究分野

ライフサイエンス / 薬系化学、創薬科学 /
ナノテク・材料 / ナノ構造化学 /

主な研究業績

Molecular-level insights into the supramolecular gelation mechanism of urea derivative

Shinya Kimura*, Kurea Adachi, Yoshiki Ishii, Tomoki Komiyama, Takuho Saito, Naofumi Nakayama, Masashi Yokoya, Hikaru Takaya, Shiki Yagai*, Shinnosuke Kawai*, Takayuki Uchihashi*, Masamichi Yamanaka

Nature Communications, 2025, 16, 3758.
Supramolecular Gel

Shinya Kimura, Masamichi Yamanaka

Routledge Resources Online – Polymers, Materials, and Technology, CRC Press, 2025.
Dispersion control by using a bulky surfactant medium in the LB films for the enhancement of linearly polarized luminescence of Eu complexes

Keiichiro Ozawa, Hideyuki Tanaka, Hitomi Ohmagari, Megumi Ishii, Shinya Kimura, Kenta Goto, Shogo Kawaguchi, Masamichi Yamanaka*, Miki Hasegawa*

Pure and Applied Chemistry, 2023, 95, 733-741.
Metal ion-assisted supramolecular gelation

Shinya Kimura, Masamichi Yamanaka*

Pure and Applied Chemistry, 2023, 95, 633-642.
Simple Strategy for Benzo[g]chromene Synthesis via a Photochemical Intramolecular Cyclization Reaction

Masashi Yokoya*, Ryo Fujimoto, Tomoki Kato, Taku Hashimoto, Shinya Kimura, Naoki Saito, Masamichi Yamanaka

The Journal of Organic Chemistry, 2023, 88, 8714-8721.
Bovine serum albumin hydrogel formation: pH dependence and rheological analyses

Shinya Kimura, Tomoki Komiyama, Tatsuki Masuzawa, Masashi Yokoya, Takanori Oyoshi*, Masamichi Yamanaka*

Chemical and Pharmaceutical Bulletin, 2023, 71(3), 229–233.
Simple strategy for benzo[de]chromene‐7,8‐dione synthesis via tandem Sonogashira coupling and intramolecular cyclization reactions

Masashi Yokoya*, Takaaki Ishiguro, Yoshiaki Sakairi, Shinya Kimura, Yuji Morita*, Masamichi Yamanaka

Asian Journal of Organic Chemistry, 2022, 11(11), e202200534.
Multiple stimuli-responsive supramolecular gel formed from modified adenosine

Shinya Kimura, Sota Mori, Masashi Yokoya, Masamichi Yamanaka*

Chemical and Pharmaceutical Bulletin, 2022, 70(6), 443–447.
Inhibition of BACE1 and amyloid β aggregation by polyketide from Streptomyces sp.

Masashi Yokoya*, Keiyo Nakai, Miki Kawashima, Sanae Kurakado, Natchanun Sirimangkalakitti, Yoshihiro Kino, Takashi Sugita, Shinya Kimura, Masamichi Yamanaka, Naoki Saito

Chemical Biology & Drug Design, 2022, 99(2), 264–276.
Formation of pH-responsive supramolecular hydrogels in basic buffers: Self-assembly of amphiphilic tris-urea

Shinya Kimura, Nana Haraya, Tomoki Komiyama, Masashi Yokoya, Masamichi Yamanaka*

Chemical and Pharmaceutical Bulletin, 2021, 69(11), 1131–1135.
Effect of alkyl chain length of N-alkyl-N’-(2-benzylphenyl)ureas on gelation

Tomoki Komiyama, Yoko Harada, Takayuki Hase, Sota Mori, Shinya Kimura, Masashi Yokoya, Masamichi Yamanaka*

Chemistry An Asian Journal, 2021, 16(13), 1750–1755.(Selected as Front Cover)
Enzymatic hydrolysis-responsive supramolecular hydrogels composed of maltose-coupled amphiphilic ureas

Ryohei Yoshisaki, Shinya Kimura, Masashi Yokoya, Masamichi Yamanaka*

Chemistry An Asian Journal, 2021, 16(14), 1937–1941.
Biological-stimuli-responsive supramolecular hydrogels toward medicinal and pharmaceutical applications

Shinya Kimura, Masashi Yokoya, Masamichi Yamanaka*

Chemistry Letters, 2021, 50(3), 459–466.
Urea derivatives as functional molecules: supramolecular capsules, supramolecular polymers, supramolecular gels, artificial hosts, and catalysts

Masashi Yokoya, Shinya Kimura, Masamichi Yamanaka*

Chemistry A European Journal, 2021, 27(18), 5601–5614.
Construction of the pentacyclic core and formal total synthesis of (rac)-renieramycin T

Shinya Kimura, Naoki Saito*

ChemistryOpen, 2018, 7 (10), 764-771. (Selected as Front Cover Picture)
A stereocontrolled total synthesis of (±)-saframycin A

Shinya Kimura, Naoki Saito*

Tetrahedron, 2018, 74 (34), 4504-4514.
Preparation of chiral right-half models of antitumor bistetrahydroisoquinolinequinone natural products

Yuuki Senbonmatsu, Shinya Kimura, Megumi Akiba, Shingo Ando, Naoki Saito*

Heterocycles, 2018, 97 (2), 1050-1067.
Semisynthesis and biological evaluation of prenylated resveratrol derivatives as multi-targeted agents for Alzheimer’s disease

Thanchanok Puksasook, Shinya Kimura, Sarin Tadtong, Jutamas Jiaranaikulwanitch, Jaturong Pratuangdejkul, Worawan Kitphati, Khanit Suwanborirux, Naoki Saito, Veena Nukoolkarn*

Journal of Natural Medicines, 2017, 71, 665-682.
The first asymmetric total synthesis of lycoposerramine-R

Hiroaki Ishida, Shinya Kimura, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama*

Organic & Biomolecular Chemistry, 2015, 13 (28), 7762-7771.
Total synthesis of (±)-lycoposerramine-R, a novel skeletal type of Lycopodium alkaloid

Hiroaki Ishida#, Shinya Kimura#, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama* (#equally contributed author)

Tetrahedron, 2015, 71 (1), 51-56.
Synthetic studies on saframycin antibiotics: An improved synthesis of tricyclic lactam intermediate and construction of the core ring system of saframycin A

Shinya Kimura, Shintaro Kawai, Masayuki Azuma, Yoshifumi Umehara, Yu-ichi Koizumi, Masashi Yokoya, Naoki Saito*

Heterocycles, 2015, 90 (1), 327-343.
Isolation, structure characterization, and synthesis of stabilized 1,2,3,4-tetrahydroisoquinoline marine natural product from potassium cyanide pretreated Thai tunicate, Ecteinascidia thurstoni

Shinya Kimura, Waree Pangkruang, Masashi Yokoya, Amane Honda, Ploenthip Puthongking, Khanit Suwanborirux*, Naoki Saito*

Heterocycles, 2014, 88 (1), 363-375.

所属学協会

日本薬学会
有機合成化学協会
基礎有機化学会
日本化学会

社会・学術貢献活動

第45回光化学若手の会

世話人
2024年6月14–16日
The 19th International Symposium on Macrocyclic and Supramolecular Chemistry 2025 (ISMSC2025)

Local Organization Committee
May 25th–30th, 2025