助教：木村　真也（キムラ　シンヤ）

薬化学

千葉大学大学院薬学研究科修士課程（2011年3月）

博士（薬科学）（千葉大学：2019年）

薬の科学実習Ⅰ、薬科学総合演習・実習、薬化学特論

有機化学、超分子化学

・生物活性天然物の全合成と医薬化学研究

・機能性超分子材料の開発

日本薬学会、有機合成化学協会、基礎有機化学会

Isolation, structure characterization, and synthesis of stabilized 1,2,3,4-tetrahydroisoquinoline marine natural product from potassium cyanide pretreated Thai tunicate, Ecteinascidia thurstoni, Shinya Kimura, Waree Pangkruang, Masashi Yokoya, Amane Honda, Ploenthip Puthongking, Khanit Suwanborirux, Naoki Saito, Heterocycles, 88, 363–375 (2014).

Synthetic studies on saframycin antibiotics: an improved, synthesis of tricyclic lactam intermediate and construction of the core ring system of saframycin A, Shinya Kimura, Shintaro Kawai, Masayuki Azuma, Yoshifumi Umehara, Yu-ichi Koizumi, Masashi Yokoya, Naoki Saito, Heterocycles, 90, 327–343 (2014).

Total synthesis of (±)-lycoposerramine-R, a novel skeletal type of Lycopodium alkaloid, Hiroaki Ishida, Shinya Kimura, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama, Tetrahedron, 71, 51–56 (2015). H. Ishida and S. Kimura contributed equally to this work.

The first asymmetric total synthesis of lycoposerramine-R, Hiroaki Ishida, Shinya Kimura, Noriyuki Kogure, Mariko Kitajima, Hiromitsu Takayama, Organic & Biomolecular Chemistry, 13, 7762–7771 (2015).

Semisynthesis and biological evaluation of prenylated resveratrol
derivatives as multi-targeted agents for Alzheimer’s disease, Thanchanok Puksasook, Shinya Kimura, Sarin Tadtong, Jutamas Jiaranaikulwanitch, Jaturong Pratuangdejkul, Worawan Kitphati, Khanit Suwanborirux, Naoki Saito, Veena Nukoolkarn, Journal of Natural Medicines, 71, 665–682 (2017).

Preparation of chiral right-half models of antitumor bistetrahydroisoquinolinequinone natural products, Yuuki Senbonmatsu, Shinya Kimura, Megumi Akiba, Shingo Ando, Naoki Saito, Heterocycles, 97, 1050–1067 (2018).

A stereocontrolled total synthesis of (±)-saframycin A, Shinya Kimura, Naoki Saito, Tetrahedron, 74, 4504–4514 (2018).

Construction of the pentacyclic core and formal total synthesis of (rac)-renieramycin T, Shinya Kimura, Naoki Saito, ChemistryOpen, 7, 764–771 (2018). Selected as a front cover picture.

Urea derivatives as functional molecules: supramolecular capsules, supramolecular polymers, supramolecular gels, artificial hosts, and catalysts, Masashi Yokoya, Shinya Kimura, Masamichi Yamanaka, Chemistry A European Journal, 27, 5601–5614 (2021).

Biological-stimuli-responsive supramolecular hydrogels toward medicinal and pharmaceutical applications, Shinya Kimura, Masashi Yokoya, Masamichi Yamanaka, Chemistry Letters, 50, 459–466 (2021).

Enzymatic hydrolysis-responsive supramolecular hydrogels composed of maltose-coupled amphiphilic ureas, Ryohei Yoshisaki, Shinya Kimura, Masashi Yokoya, Masamichi Yamanaka, Chemistry An Asian Journal, 16, 1937–1941 (2021).

Effect of alkyl chain length of N-alkyl-N’-(2-benzylphenyl)ureas on gelation, Tomoki Komiyama, Yoko Harada, Takayuki Hase, Sota Mori, Shinya Kimura, Masashi Yokoya, Masamichi Yamanaka, Chemistry An Asian Journal, 16, 1750–1755 (2021). Selected as Front Cover

ノバルティス科学振興財団　研究奨励金（2020）中枢への薬物輸送を可能にする超分子ヒドロゲルの開発