Molecular and Cellular Biochemistry

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We study the roles of the nucleolar molecular chaperone-like protein NVL2 in RNA metabolism. Our goal is to elucidate the molecular functions of NVL2, including its involvement in ribosomal RNA maturation. We aim to contribute to the development of innovative anticancer drugs targeting NVL2.

Members

NAGAHAMA MASAMI Professor

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IZUMIKAWA KEIICHI Associate Professor

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Research Topics

Functional analysis of the nucleolar chaperon NVL2 in ribosome biogenesis
Elucidation of the nucleolar stress response caused by AAA-ATPase NVL2 dysfunction
Elucidation of the non-coding RNA metabolism involving MTR4-RNA exosome co-factor SPF30 (SMNDC1)

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