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Improved Preparation of Methyl Bis(2,2,2-trifluoroethoxy)bromophosphonoacetate for the Stereoselective Synthesis of
(E)-α-Bromoacrylates: Akiko Nakata, Kenichi Kobayashi, and Hiroshi Kogen, Chem. Pharm. Bull. 61, 108-110 (2013).
 

Development of an Efficient Therapeutic Agent for Alzheimer's Disease: Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter: N. Toda, T. Kaneko, H. Kogen, Chem. Pharm. Bull. 56, 273-287 (2010).

 

Mayuko Ori, Narihiro Toda, Kazuko Takami, Keiko Tago, and Hiroshi Kogen: Stereospecific synthesis of 2,2,3-trisubstituted tetrahydroquinolines: application to the total syntheses of benzastatin E and natural virantmycin. Tetrahedron 61, 2075-2104 (2005).

 

Toshihiro Kiho, Mizuka Nakayama, Kayo Yasuda, Shunichi Miyakoshi, Masatoshi Inukai, and Hiroshi Kogen: Structure Activity Relationships of Globomycin Analogues as Antibiotics. Bioorg. Med. Chem. 12, 337-361 (2004).

 

Toshihiro Kiho, Yoriko Iwata, Hiroshi Kogen, Shuichi Miyamoto: Conformational Analysis of Globomycin with a Signal Peptidase II Inhibitor Activity Using Molecular Dynamics Simulation. Drug Des. Discovery 18, 109-116 (2003).

 

Takekazu Kubo, Satoko Nishimura, Takako Murasugi, Isao Kaneko, Masaki Meguro, Shinji Marumoto, Hiroshi Kogen, Kazuo Koyama, Tomiichiro Oda, and Yasuhiro Nakagami: 6-Ethyl-N,N'-bis(3-hydroxyphenyl)[1,3,5]triazine-2,4-diamine (RS-0466) Enhances the Protective Effect of Brain-derived Neurotrophic Factor on Amyloid b-Induced Cytotoxicity in Cortical Neurones. Pharmacol. Toxicol. 93, 264-268 (2003).

 

Satoko Nishimura, Takako Murasugi, Takekazu Kubo, Isao Kaneko, Masaki Meguro, Shinji Marumoto, Hiroshi Kogen, Kazuo Koyama, Tomiichiro Oda, and Yasuhiro Nakagami: RS-4252 Inhibits Amyloid b-Induced Cytotoxicity in HeLa Cells. Pharmacol. Toxicol. 93, 29-32 (2003).

 

Yasuyuki Abe, Atsushi Aoyagi, Takao Hara, Kazumi Abe, Reina Yamazaki, Yoshihiro Kumagae, Shunji Naruto, Kazuo Koyama, Shinji Marumoto, Keiko Tago, Narihiro Toda, Kazuko Takami, Naho Yamada, Mayuko Ori, Hiroshi Kogen, and Tsugio Kaneko: Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter in rodents: possible treatment of Alzheimer’s disease. J. Pharmcol. Sci. 93, 95-105 (2003).

 

Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kaneko, and Hiroshi Kogen: A Conformational Restriction Approach to the Development of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter as Potential Agents for Alzheimer’s Disease. Bioorg. Med. Chem. 11, 4389-4415 (2003).

 

Narihiro Toda, Yoriko Iwata, Keiko Tago, Hiroshi Kogen, Tsugio Kaneko, and Shuichi Miyamoto: Conformational Analysis and Docking Study of Potent Acetylcholinesterase Inhibitors Having a Benzylamine Moiety. Chem-Bio Informatics J. 3, 46-57 (2003).

 

Mayuko Ori, Narihiro Toda, Kazuko Takami, Keiko Tago, and Hiroshi Kogen: Stereospecific Construction of Contiguous Quaternary and Tertiary Stereocenters by  Rearrangement from Indoline-2-methanol to 2,2,3-Trisubstituted Tetrahydroquinoline: Application to an Efficinet Total Synthesis of Natural Virantmycin. Angew. Chem. Int. Ed. 125, 2540-2543 (2003).

 

Toshihiro Kiho, Mizuka Nakayama, Kayo Yasuda, Shunichi Miyakoshi, Masatoshi Inukai, and Hiroshi Kogen: Synthesis and Antimicrobial Activity of Novel Globomycin Analogues. Bioorg. Med. Chem. Lett. 13, 2315-2318 (2003).

 

Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kaneko, and Hiroshi Kogen: Design, Synthesis and Structure–Activity Relationships of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter as Potential Agents for Alzheimer’s Disease. Bioorg. Med. Chem. 11, 1935-1955 (2003).

 

Toshihiro Kiho, Mizuka Nakayama, and Hiroshi Kogen: Total synthesis and NMR conformational study of signal peptidase II inhibitors, globomycin and SF-1902 A5. Tetrahedron 59, 1685-1697 (2003).

 

Narihiro Toda, Mayuko Ori, Kazuko Takami, Keiko Tago, and Hiroshi Kogen: Total Synthesis of (+)-Benzastatin E via Diastereoselective Grignard Addition to 2-Acylindoline. Org. Lett. 5, 269-271 (2003).

 

Yasuhiro Nakagami, Satoko Nishimura, Takako Murasugi, Isao Kaneko, Masaki Meguro, Shinji Marumoto, Hiroshi Kogen, Kazuo Koyama, and Tomiichiro Oda: A Novel b-Sheet Breaker, RS-0406, Reverses Amiloid b-Induced Cytotoxicity and Impairment of Long-term Potentiation in vitro. Br. J. Pharmacol. 137, 676-682 (2002).

 

Yasuhiro Nakagami, Satoko Nishimura, Takako Murasugi, Takekazu Kubo, Isao Kaneko, Masaki Meguro, Shinji Marumoto, Hiroshi Kogen, Kazuo Koyama, and Tomiichiro Oda: A Novel Compound RS-0466 reverses b-Amiloid-induced Cytotoxicity through the Akt Signaling Pathway in vitro. Eur. J. Pharmacol. 457, 11-17 (2002).

 

Hiroshi Kogen, Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, and Tsugio Kaneko: Design and Synthesis of Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter Targeting Potential Agents for Alzheimer's Disease. Org. Lett. 4, 3359-3362 (2002).

 

Keiko Tago, Emiko Minami, Kayoko Masuda, Toshiyuki Akiyama and Hiroshi Kogen: Synthesis of Plaunotol Derivatives and their Antibacterial Activities against Helicobacter pylori. Bioorg. Med. Chem. 9, 1781-1791 (2001).

 

Hiroshi Kogen, Toshihiro Kiho, Mizuka Nakayama, Youji Furukawa, Takeshi Kinoshita, and Masatoshi Inukai: Crystal Structure and Total Synthesis of Globomycin: Establishment of Relative and Absolute Configuration. J. Am. Chem. Soc. 122, 10214-10215 (2000).

 

Conformational Analysis and Docking Study of Potent Factor XIIIa Inhibitors Having a Cyclopropenone Ring

Yoriko Iwata, Keiko Tago, Toshihiro Kiho, Hiroshi Kogen, Tomoyuki Fujioka, Noriko Otsuka, Keiko Suzuki-Konagai, Takeshi Ogita, and Shuichi Miyamoto; J. Mol. Graphics Modell.18, 591-599 (2000).

 

A highly stereoselective synthesis of (E)-a-bromoacrylates

Keiko Tago and Hiroshi Kogen; Tetrahedron 56, 8825-8831 (2000).

 

Hiroshi Kogen, Toshihiro Kiho, Keiko Tago, Shuichi Miyamoto, Tomoyuki Fujioka, Noriko Otsuka, Keiko Suzuki-Konagai, and Takeshi Ogita: Alutacenoic Acids A and B, Rare Naturally Occurring Cyclopropenone Derivatives Isolated from Fungi: Potent Non-Peptide Factor XIIIa Inhibitors. J. Am. Chem. Soc. 122, 1842-1843 (2000).

 

Keiko Tago and Hiroshi Kogen: Bis(2,2,2-trifluoroethyl)bromophosphonoacetate, a Novel HWE Reagent for the Preparation of (E)-a-Bromoacrylates: A General and Stereoselective Method for the Synthesis of Trisubstituted Alkenes. Org. Lett. 2, 1975-1978 (2000).

 

Keiko Tago, Masami Arai and Hiroshi Kogen: A Practical Total Synthesis of Plaunotol via Highly Z-selective Wittig Olefination of a-Acetal Ketones. J. Chem. Soc., Perkin Trans. 1 2073-2078 (2000).

 

Shoichi Saito, Natsuki Tanaka, Katumi Fujimoto, and Hiroshi Kogen: Absolute Configuration of Scyphostatin. Org. Lett. 2, 505-506 (2000).

 

Hiroshi Kogen, Keiko Tago, Masami Arai, Emiko Minami, Kayoko Masuda, and Toshiyuki Akiyama: A Highly Stereoselective Synthesis of Plaunotol and Its Thiourea Derivatives as Potent Antibacterial Agents against Helicobacter Pylori. Bioorg. Med. Chem. Lett. 9, 1347-1350 (1999).

 

Shinji Marumoto, Hiroshi Kogen, and Shunji Naruto: Synthetic study on L-755,807: Asymmetric synthesis of the epoxy-g-lactam moiety. Tetrahedron: Asymmetry 10, 675-678 (1999).

 

Shinji Marumoto, Hiroshi Kogen, and Shunji Naruto: Asymmetric total synthesis of epolactaene. Part 2: Introduction of the side chain and synthesis of (+)-epolactaene and its enantiomer. Tetrahedron 55, 7145-7156 (1999).

 

Shinji Marumoto, Hiroshi Kogen, and Shunji Naruto: Asymmetric total synthesis of epolactaene. Part 1: Construction of epoxy-g-lactam moiety and deduction of absolute stereochemistry. Tetrahedron  55, 7129-7144 (1999).

 

Shinji Marumoto, Hiroshi Kogen, and Shunji Naruto: 1,2-Asymmetric Induction in the Aldol Addition Reaction of Malonate Ester Enolate to a-Alkoxy Aldehyde. Chem. Comm. 2253-2254 (1998).

 

Shinji Marumoto, Hiroshi Kogen, and Shunji Naruto: Absolute Configuration and Total Synthesis of (+)-Epolactaene, a Neuritogenic Agent from Penicillium sp. BM 1689-P Active in Human Neuroblastoma Cells. J. Org. Chem. 63, 2068-2069 (1998).

 

Hiroshi Kogen, Keiko Tago, Satoru Kaneko, Kiyoshi Hamano, Kaori Onodera, Hideyuki Haruyama, Katsuhiro Minagawa, Takeshi Kinoshita, Tomio Ishikawa, Tatuo Tanimoto, and Yoshio Tujita: Schizostatin, a Novel Squalene Synthase Inhibitor Produced by the Mushroom, Schizophyllum commune; 2. Structure Elucidation and Total synthesis. J. Antibiot. 49, 624-630 (1996).

 

Tatuo Tanimoto, K. Onodera, Y. Takamatsu, Takeshi Kinoshita, Keiko Tago, Hiroshi Kogen, Fujioka, Kiyoshi Hamano, and Yoshio Tujita: Schizostatin, a Novel Squalene Synthase Inhibitor Produced by the Mushroom, Schizophyllum commune; 1. Taxonomy, Fermentation, Isolation, Physico-chemical Propaties and Biological Activities. J. Antibiot. 49, 617-623 (1996).

 

Tatuo Tanimoto, Yoshio Tujita, Kiyoshi Hamano, Hideyuki Haruyama, Takeshi Kinoshita, Tsuyoshi Hosoya, Satoru Kaneko, Keiko Tago, and Hiroshi Kogen: Schizostatin, a potent squalene synthase inhibitor from Schizophyllum commune: Isolation, structure elucidation, and total synthesis. Tetrahedron Lett. 36, 6301-6304 (1995).

 

Hiroshi Kogen, Masaaki Kurabayashi, and Hiroshi Kadokawa: An Efficient Stereocontrolled Synthesis of (-)-Detoxinine. J. Chem. Soc., Chem. Commun. 1240-1212 (1990).

 

Paul A. Wender, Hiroshi Kogen, Hee Y. Lee, John D. Munger, Jr., Robert S. Wilhelm, and Peter D. Williams: Studies on Tumor Promoters. 8. The Synthesis of Phorbol. J. Am. Chem. Soc. 111, 8957-8958 (1989).

 

Hiroshi Kogen and Takahide Nishi: Diastereoselective Epoxidation of cis-4-Amino Allylic Alcohol with m-Chloroperbenzoic Acid. An Efficient Synthesis of Statine. J. Chem. Soc., Chem. Commun. 311-312 (1987).

 

Tozo Fujii, Yukimi Takai, Masashi Ohba, Hiroshi Kogen, and Michinori Oki: Lactams. XXV.  Reassignments of the carbon:carbon and carbon:oxygen stretching vibrations in six-membered a,b-unsaturated lactams. Chem. Pharm. Bull. 33, 2697-2704 (1985).

 

Tozo Fujii, Hiroshi Kogen, Shigeyuki Yoshifuji, and Masashi Ohba: Quinolizidines.  XIII.  Syntheses of (±)- and (-)-alangimarckines. Chem. Pharm. Bull. 33, 1946-1954 (1985).

 

Rei Matsueda, Yuichiro Yabe, Hiroshi Kogen, Susumu Higashida, Hiroyuki Koike, Yasuteru Iijima, Tatsuo Kokubu, Kunio Hiwada, Eiki Murakami, and Yoichi Imamura: Short chain peptide inhibitors of human rennin. Chem. Lett. 1041-1044 (1985).

 

T. Kokubu, K. Hiwada, Y. Sato, T. Iwata, Y. Imamura, R. Matsueda, Y. Yabe, H. Kogen, M. Yamazaki, Y. Iijima, and Y. Baba: Highly potent and specific inhibitors of human rennin. Biochem. Biophys. Res. Commun. 118, 929-933 (1984).

 

Hiroshi Kogen, Kiyoshi Tomioka, Shunichi Hashimoto, and Kenji Koga: Stereoselective reactions. IV. Diastereoselective and enantioselective synthesis of 1,2-disubstituted cycloalkanecarboxaldehydes. Tetrahedron, 37, 3951-3956 (1981).

 

Tozo Fujii, Masashi Ohba, Hiroshi Kogen, and Yuko Ueda: Lactams. XX. Decarboxylation of unsaturated acids incorporated into six-membered lactam systems. Chem. Pharm. Bull. 29, 3392-3397 (1981).

 

Hiroshi Kogen, Kiyoshi Tomioka, Shunichi Hashimoto, and Kenji Koga: Asymmetric synthesis of 1,2-disubstituted cycloalkanecarboxaldehydes. procedures for the highly stereoselective preparation of cis- and trans-isomer. Tetrahedron Lett. 21, 4005-4008 (1980).

 

Shunichi Hashimoto, Hiroshi Kogen, Kiyoshi Tomioka, and Kenji Koga: Asymmetric synthesis of 2-substituted cycloalkanecarboxaldehydes. Tetrahedron Lett. 20, 3009-3012 (1979).

 

Tozo Fujii, Hiroshi Kogen, Shigeyuki Yoshifuji, and Kiyomi Iga: Lactams. XV. Chemistry of Unsaturated d-Valerolactams. Chem. Pharm. Bull. 27, 1847-1856 (1979).

 

 (-)-Alangimarckine: Synthesis and absolute configuration of an alangium alkaloid: Tozo Fujii, Hiroshi Kogen, and Masashi Ohba: Tetrahedron Lett. 19, 3115-3118 (1978).

 

Tozo Fujii, Shigeyuki Yoshifuji, and Hiroshi Kogen: Structure and relative stereochemistry of alangimarckine: a total synthesis of (±)-alangimarckine. Tetrahedron Lett. 18, 3477-3480 (1977).

 

総説(日本語)

1b) 古源 寛: 腫瘍促進物質Phorbol Esterの合成. 有機合成化学協会誌, 48, 724-737 (1990).

 

2b) 古源 寛: 発癌プロモーターホルボールエステルの化学:ホルボールの全合成. 化学と生物, 31, 300-307 (1993).

 

3b) 丸本 真志,古源 寛: エポラクタエンの不斉全合成. 有機合成化学協会誌, 58, 183-191 (2000).

 

4b) 多胡 敬子,古源 寛: 汎用的かつ立体選択的な三置換オレフィン構築法の開発とそれを用いたプラウノトールの効率的全合成. 有機合成化学協会誌, 59, 971-984 (2001).

 

5b) 木方 俊宏,古源 寛: 新規抗菌剤の開発を指向したグロボマイシン類の合成研究. 有機合成化学協会誌, 63, 51-62 (2005).

 

著書(英語)

1c) Dual Inhibitors of Acetylcholinesterase and Serotonin Transporter Targeting Potential Agents for Alzheimer’s Disease

Narihiro Toda, Tsugio Kaneko, and Hiroshi Kogen; “Trends in Serotonin Uptake Inhibitors Research”, Anne C. Shirley ed., Nova Science Publishers, Inc., New York, 2005, pp73-103.

 

招待講演等

1d) “Complete Stereochemical Structure and Asymmetric Total Synthesis of Globomycin”

Hiroshi Kogen; 2000年 1215 環太平洋国際化学会議 招待講演(ホノルル

 

2d)“創薬を指向した生物活性天然物の合成研究”

古源 寛; 2002年 626 金沢大学薬学部 特別講演

 

3d) “Synthesis and Absolute Configuration of Globomycin, a 19-Membered Cyclic Depsipeptide Antibiotic”

Hiroshi Kogen; 2002年 1022日 8th International Conference on Chemistry of Antibiotics and Related Microbial Products Plenary Lecture(東京)

 

4d)“生合成仮説に基づくインドリン骨格からテトラヒドロキノリン骨格への変換”

古源 寛; 2003年 129 東京工業大学工学部 特別講演

 

5d)“創薬を指向した生物活性天然物及び誘導体の合成研究”

古源 寛; 2003年 1031日 奈良先端科学技術大学院大学 特別講演

 

6d)“大環状デプシペプチド抗生物質の全合成”

古源 寛; 2003年 1114日 東京工業大学工学部 特別講演

 

7d)“創薬を指向した生物活性天然物およびその誘導体の合成研究”

古源 寛; 2004年 331 日本薬学会第124年会 シンポジウム「創薬における天然物合成の意義」 招待講演(大阪)

 

8d)“生合成仮説に基づくインドリン骨格からテトラヒドロキノリン骨格への変換”

古源 寛; 2005年 328 古賀憲司先生追悼シンポジウム 招待講演(東京大学薬学部)

 

特許,公開特許等

 

Preparation of phenyl dimethylcarbamate analogues as inhibitors of acetylcholinesterase and Serotonin reuptake, K. Koyama, S. Marumoto, N. Toda, H. Kogen, K. Suzuki, US 20080255095.

 

小山和男; 丸本 真志; 戸田 成洋; 鈴木 敬子; 古源寛

特開2004-107322 (200448, 141)

ヒドロキシベンジルアミン誘導体を含有する医薬 (Preparation of alkylcarbamic acid esters as acetylcholinesterase inhibitor and serotonin reuptake inhibitor)

 

古源寛; 宮崎 敦広; 早川 市郎; 田村 明弘

特開2004-18499 (2004122, 72)

アミド誘導体を含有する医薬組成物 (Preparation of N-(2-tert-butylphenyl)-2-(3,5-dimethylphenylamino)acetamide derivatives as acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors)

 

小山和男; 丸本 真志; 戸田 成洋; 鈴木 敬子; 古源寛

特開2003-176256 (2003624, 119), PCT Int. Appl. WO2002059074 (1 Aug, 2002, 300pp)

ヒドロキシベンジルアミン誘導体 (Preparation of alkylcarbamic acid esters as acetylcholinesterase inhibitor and serotonin reuptake inhibitor)

 

 

古源寛; 宮崎 敦広; 早川 市郎; 田村 明弘

特開2002-249474 (200296, 45), PCT Int. Appl. WO2002051796 (4 Jul, 2002, 109pp)

アミド誘導体 (Preparation of N-(2-tert-butylphenyl)-2-(3,5-dimethylphenylamino)acetamide derivatives as acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors)

古源寛; 宮崎 敦広; 早川 市郎; 田村 明弘

 

鈴木敬子; 古源寛

特開2001-261619 (2001926, 15)

三置換オレフィン類の製法 (Preparation of (E)-haloalkenoic acid esters)

 

古源寛; 荻田

特開2000-169416 (2000620, 85)

シクロプロペノン誘導体 (Preparation of cyclopropenones derivatives as inhibitors of blood coagulation factor XIIIa)

 

古源寛; 田村 明弘; 早川 市郎; 古賀 貞一郎

 特開平11-158133 (1999615, 60)

フェノール誘導体 (Preparation of N-(2-tert-butylphenyl)-3-(hydroxyphenyl)propanamide derivatives for treatment of arteriosclerotic diseases and myocardial infarction)

 

成戸俊二; 丸本 真志; 古源寛

特開平11-130765 (1999518, 45)

エポキシエタン誘導体 (Epoxyethanes or their salts)

 

吉田明; 小田 晃造; 古源寛; 古賀 貞一郎

特開平10-316641 (1998122, 87)

カルボン酸誘導体

 

吉田明; 小田 晃造; 笠井 ; 島田 神生; 古源寛; 早川 市郎; 石原 貞夫; 古賀 貞一郎; 北沢 栄一; 徳井 太郎

特開平10-316562 (1998122, 127)

抗動脈硬化剤

 

古源寛; 荒井 雅巳; 早川 市郎

特開平10-77241 (1998324, 13)

鎖状テルペン誘導体の中間体の製法

 

吉田明; 古源寛; 早川 市郎; 小田 晃造; 笠井 ; 島田 神生; 吉田 有美; 石原 貞夫; 斎藤 冨士夫; 大畑 靖雄; 古賀 貞一郎; 北沢 栄一; 徳井 太郎

特開平9-202775 (199785, 95)

-フェニルアミド及び尿素誘導体を含有する医薬 (Preparation of heterocyclylphenylurea and amide derivatives)

 

吉田明; 小田 晃造; 笠井 ; 島田 神生; 古源寛; 早川 市郎; 石原 貞夫; 古賀 貞一郎; 北沢 栄一; 徳井 太郎

特開平9-143137 (199763, 129), Eur. Pat. Appl. EP763524 A1 (19 Mar, 1997, 280pp)

アミド及び尿素誘導体 (Preparation of N-(carbamoylphenyl)alkanamides and analogs as cholesterol acyltransferase inhibitors)

 

吉田 ; 古源 ; 早川 市郎; 小田 晃造; 笠井 ; 島田 神生; 石原 貞夫; 斎藤 冨士夫; 大畑 靖雄; 古賀 貞一郎; 北沢 栄一; 徳井 太郎

特開平8-325218 (19961210, 165)

フェニルプロピオン酸アミド及びN-フェネチル尿素体 (Preparation of N-phenylamides and N-phenylureas as ACTA inhibitors and as cholesterol-lowering and antiarteriosclerotic agents)

 

吉田 ; 古源 ; 早川 市郎; 小田 晃造; 笠井 ; 島田 神生; 吉田 有美; 石原 貞夫; 斎藤 冨士夫; 大畑 靖雄; 古賀 貞一郎; 北沢 栄一; 徳井 太郎

特開平8-92222 (199649, 97), PCT Int. Appl. WO9603378 (8 Feb, 1996, 232pp)

フェニルアミド及び尿素誘導体 (Preparation of heterocyclylphenylurea and amide derivatives)

 

吉田 ; 小田 晃造; 笠井 ; 石原 貞夫; 斎藤 冨士夫; 小池 博之; 古賀 貞一郎; 北沢 栄一; 古源 ; 早川 市郎

特開平7-70021 (1995314, 197), Eur. Pat. Appl. EP632036 A2 (4 Jan, 1995, 365pp)

アミド及び尿素誘導体 (Preparation of xanthenylacetamide and -urea derivatives as anticholesteremics and antiarteriosclerotics)

 

石原貞夫; 古源寛; 古賀 貞一郎; 北沢 栄一; 芹澤 伸記

特開平6-279280 (1994104, 97), Eur. Pat. Appl. EP609058 A2 (3 Aug, 1994, 173pp)

エステル化合物 (Preparation of hexahydronaphthalene ester derivatives, as anticholesteremics)

 

古源寛; 石原 貞夫; 古賀 貞一郎; 北沢 栄一; 芹澤 伸記; 浜野

特開平6-247894 (199496, 75), Eur. Pat. Appl. EP605230 A1(6 Jul, 1994, 154pp)

エステル誘導体 (Preparation of hexahydronaphthyl ester anticholesteremics)

 

古源 ; 倉林 正明; 古賀 貞一郎; 駒井 ; 岩渕 晴男

特開平6-41040 (1994215, 38), Eur. Pat. Appl. EP570245 A2 (18 Nov, 1993, 97pp)

5-オキソオクタヒドロナフタリン置換オキシム誘導体 (Preparation of octahydronaphthalenone oxime derivatives for cholesterol biosynthesis inhibition)

 

矢部 裕一郎; 古源 ; 西 剛秀

特公平7-25744 (1995322, 19)

アミノエポキシアルコ-ル誘導体

 

倉林正明; 古源寛; 門川 博志; 栗原 英志; 長谷川和雄; 黒田 正夫

特許第2542429 (1996725, 38), Eur. Pat. Appl. EP314435 A2 (3 May, 1989, 72pp)

オクタヒドロナフタリン置換オキシム誘導体 (Octahydronaphthalene oxime derivatives as cholesterol synthesis inhibitors, processes for their preparation, and compositions containing them)

 

 

その他(日本語)

1f)古源 寛: 薬学部卒業生の将来. ファルマシア 31, 355-360 (1995).

2f) 古源 寛: 有機合成化学に魅せられて. ファルマシア 33, 1087-1092 (1997).

 

3f) 荻田 健古源 寛: シクロプロペノン環をもつXIIIa血液凝固因子阻害物質:微生物培養液から見出されたアルタセン酸の化学と阻害メカニズム. 化学と生物 39, 6-7 (2001).

 

英語

4f) T. Kiho and H. Kogen: Synthetic Study and Development of New Antibiotics, Globomycin and Its Analogues. Annu. Rep. Sankyo Res. Labs. 57, 43-58 (2005).

 

以上


受賞・メディア紹介実績
2010年3月 当研究室の論文がChemical & Pharmaceutical Bulletin 誌の3月号に掲載され、表紙のイラストに選ばれました。