研究

研究室

教授:三田 充男(ミタ ミツオ)

役職名

動物研究施設長

研究室

循環薬理学

最終学歴

明治薬科大学大学院薬学研究科博士課程(1987年3月)

学位

薬学博士(明治薬科大学:1987年)

講義科目

薬理学II、症例解析演習I・II、生命科学実習II、病院薬学コース特論・演習、院・薬学専攻・総合医療薬学特論・演習

専門分野

薬理学

研究課題

血管平滑筋の収縮調節機構とその機能障害に関する研究

所属学会

日本薬学会、日本薬理学会、日本平滑筋学会、日本循環薬理学会、日本心脈管作動物質学会、日本医療薬学会、Biophysical Society (USA)

学会活動

日本薬理学会学術評議員 (1994-)

学内委員

教務委員長(2018-2019)、コース特別実習・演習委員会(2019-2022)、病院薬学コース責任者(2017-2018)、学内実務実習委員会(2014-)、学外実務実習委員会(2016-)、OSCE実施委員会(2014-)、動物研究施設長(2018-)、動物実験委員会(2018-)、動物研究施設運営委員会(2000-)、FD委員会(2018-2019)、CBT実施委員会(2018-2019)、IR委員会(2018-)、大学院運営委員会(2018-2019)

社会活動

楽しきcollaboration. 三田充男, 内藤記念財団時報, 72, 46 (2003)、第2章末梢神経系およびその効果器に作用する薬物、薬理学-医薬品の作用、pp. 27-91、廣川書店(2005)、副交感神経に作用する薬 監修、薬がみえる vol. 1(改訂第2版)、pp. 55-76、メディックメディア (2021) 、公立昭和病院受託研究審査委員会(2017-)、公認スポーツファーマシスト

依頼公演

小平市市民講座高齢者学級「シルバー大学 第33期」(小平市、2007)

受賞歴

第28回日本臨床薬理学会優秀演題賞(2007)、Journal of Smooth Muscle Research第49巻優秀論文賞(2014)

研究業績1

Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase. Mitsuo Mita, Hayato Yanagihara, Shigeru Hishinuma, Masaki Saito and Michael P. Walsh, Biochemical Journal, 364(2), 431-440 (2002).

研究業績2

The role of RhoA and Rho-associated kinase in vascular smooth muscle contraction. Karl Sward, Mitsuo Mita, David P. Wilson, Jing Ti Deng, Marija Susnjar, Michael P. Walsh, Current Hypertension Reports, 5(1), 66-72 (2003).

研究業績3

Comparison of pharmacodynamics between carvedilol and metoprolol in rats with isoproterenol-induced cardiac hypertrophy: effects of carvedilol enantiomers. Kazuhiko Hanada, Kazuhiko Asari, Masako Saito, Jun-ichi Kawana, Mitsuo Mita, Hiroyasu Ogata, European Journal of Pharmacology, 589(1-3), 194 - 200 (2008).

研究業績4

Effect of chondroitinase on dermatan sulfate-facilitated arginine amidase released from rabbit ear artery. Reiko Ishii-Nozawa, Tatsuya Naito, Mitsuo Mita, Kyosuke Miyazaki, Yoshifumi Matsuda and Koichi Takeuchi. Biological & Pharmaceutical Bulletin, 33(1), 150-152 (2010).

研究業績5

Impairment of α1-adrenoceptor-mediated contractile activity in caudal arterial smooth muscle from Type 2 diabetic Goto-Kakizaki rats. Mitsuo Mita, Takuto Kuramoto, Kazushi Ito, Natsuko Toguchi-Senrui, Shigeru Hishinuma, Michael P. Walsh and Masaru Shoji. Clinical and Experimental Pharmacology and Physiology, 37(4), 350-357 (2010).

研究業績6

Attenuation of store-operated Ca2+ entry and enhanced expression of TRPC channels in caudal artery smooth muscle from Type 2 diabetic Goto-Kakizaki rats. Mitsuo Mita, Kazushi Ito, Kengo Taira, Jun-ichi Nakagawa, Michael P. Walsh and Masaru Shoji. Clinical and Experimental Pharmacology and Physiology, 37(7), 670-678 (2010).

研究業績7

Dysfunction of neurotransmitter modulation system on adrenergic nerves of caudal artery in Type 2 diabetic Goto-Kakizaki rats. Reiko Ishii-Nozawa, Mitsuo Mita, Masaru Shoji and Koichi Takeuchi. Biological & Pharmaceutical Bulletin, 35(7), 1091-1095 (2012).

研究業績8

Membrane depolarization-induced RhoA/Rho-associated kinase activation and sustained contraction of rat caudal arterial smooth muscle involves genistein-sensitive tyrosine phosphorylation. Mitsuo Mita, Hitoshi Tanaka, Hayato Yanagihara, Jun-ichi Nakagawa, Shigeru Hishinuma, Cindy Sutherland, Michael P. Walsh and Masaru Shoji. Journal of Smooth Muscle Research, 49, 26-45 (2013).

研究業績9

A Role for the Tyrosine Kinase Pyk2 in Depolarization-induced Contraction of Vascular Smooth Muscle. Ryan D. Mills, Mitsuo Mita, Jun-ichi Nakagawa, Masaru Shoji, Cindy Sutherland and Michael P. Walsh. The Journal of Biological Chemistry, 290(14), 8677-8692 (2015).

研究業績10

A role for the Ca2+-dependent tyrosine kinase Pyk2 in tonic depolarization-induced vascular smooth muscle contraction. Journal of Muscle Research and Cell Motility. Ryan D. Mills, Mitsuo Mita and Michael P. Walsh. Journal of Muscle Research and Cell Motility, 36(6), 479-489 (2015)

研究業績11

Differential regulation of plasma copeptin levels in patients with heart failure: A single-center prospective study. Natsuko IwashitaNoriko Nara, Ryosuke Sato, Tomoyori Nakatogawa, Shunichi Kobayashi, Sayuri Zama, Mitsuo Mita, Shigeru Hishinuma and Masaru Shoji. The Tohoku Journal of Experimental Medicine, 239(3), 213 - 221 (2016).

研究業績12

Inhibition of ectopic arginine vasopressin production by phenytoin in the small cell lung cancer cell line Lu-165. Takahiro Ohta, Mitsuo Mita, Shigeru Hishinuma, Reiko Ishii-Nozawa, Kazuhisa Takahashi and Masaru Shoji. Frontiers in Endocrinology, 28 April (2017), https://doi.org10.3389/fendo.2017.00094.

研究業績13

Analysis of risk factors for lenalidomide-associated skin rash in patients with multiple myeloma. Sugi T, Nishigami Y, Saigo H, Hanai H, Takabatake K, Mita M, Ohara S, Ide S, Uchida T, Inoue M, Hagihara M. Leuk Lymphoma, 62(6), 1405-1410 (2021).

研究業績14

Simple desensitization protocol for multiple myeloma patients with lenalidomide-induced skin rash: Case series. Sugi T, Mita M, Yasu T, Ohara S, Uchida T, Inoue M, Hagihara M. J Clin Pharm Ther., 46(6), 1792-1795 (2021).

研究業績15

Preceding bortezomib administration for a certain period reduces the risk of lenalidomide-induced skin rash. Sugi T, Mita M, Yasu T, Kubo K, Kushi R, Hanai H, Ohara S, Uchida T, Inoue M, Hagihara M. J Clin Pharm Ther., 2021 Nov 14. doi: 10.1111/jcpt.13568.