教育・研究

明治薬科大学教員総覧

講師:石田 洋一(イシダ ヨウイチ)

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研究室

生体分子学

最終学歴

京都薬科大学大学院薬学研究科薬学専攻博士課程(2003年3月)

学位

博士(薬学) (京都薬科大学:2003年)

講義科目

生命科学実習V(2年A、B、C組) 臨床生化学(3年C組) 卒業研究コースA実習 卒業研究II 卒業研究B

専門分野

細胞生物学 ウイルス学 プロテオミクス

研究課題

RNA代謝関連複合体の同定と機能解析 ウイルス性発がんの発症機構の解析

所属学会

日本薬学会 日本HTLV-1学会 日本分子生物学会 日本生化学会 日本プロテオーム学会

学内委員

学生厚生委員、進路就職支援委員、薬品管理システム運営委員

研究業績1

Yo-ichi Ishida*, Kiyoshi Yamashita, Hidenori Sasaki, Ichirou Takajou, Yoko Kubuki, Kazuhiro Morishita, Hirohito Tsubouchi, Akihiko Okayama. Activation of complement system in adult T-cell leukemia (ATL) occurs mainly through lectin pathway: a serum proteomic approach using mass spectrometry. Cancer Letters, 271, 167-177, 2008. *; Corresponding author

研究業績2

Yo-ichi Ishida*, Masao Yamasaki, Chizuko Yukizaki, Kazuo Nishiyama, Hirohito Tsubouchi, Akihiko Okayama, Hiroaki Kataoka. Carnosol, rosemary ingredient, induces apoptosis in adult T-cell leukemia/lymphoma cells via glutathione depletion; proteomic approach using fluorescent two-dimensional differential gel electrophoresis. Human Cell, 27, 68-77, 2014. *; Corresponding author

研究業績3

Yo-ichi Ishida, Maria Takikawa, Toshihiro Suzuki, Masami Nagahama, Yuki Ogasawara. Irreversible hyperoxidation of peroxiredoxin 2 is caused by tert-butyl hydroperoxide in human red blood cells. FEBS Open Bio, 4, 848-852, 2014.

研究業績4

Ogasawara Y.*, Ishida YI.*, Takikawa M., Funaki Y., Suzuki T., Koike S. A simple high performance liquid chromatography method for quantitatively determining the reduced form of peroxiredoxin 2 and the mass spectrometric analysis of its oxidative status. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences, 997, 136-141, 2015. *; Co-first authors

研究業績5

Yuki Yoshikatsu, Yo-ichi Ishida, Haruka Sudo, Keizo Yuasa, Akihiko Tsuji, Masami Nagahama. NVL2, a nucleolar AAA-ATPase, is associated with the nuclear exosome and is involved in pre-rRNA processing. Biochemical and Biophysical Research Communications, 464, 780-786, 2015.

研究業績6

Nobuhiro Hiraishi, Yo-ichi Ishida, Masami Nagahama. AAA-ATPase NVL2 acts on MTR4-exosome complex to dissociate the nucleolar protein WDR74. Biochemical and Biophysical Research Communications, 467, 534-540, 2015.

研究業績7

Haruka Sudo, Aya Nozaki, Hideaki Uno, Yo-ichi Ishida, Masami Nagahama. Interaction properties of human TRAMP-like proteins and their role in pre-rRNA 5’ETS turnover. FEBS Letters, 590, 2963-2972, 2016.

研究業績8

Yo-ichi Ishida*, Mariko Aki, Sohta Fujiwara, Masami Nagahama, Yuki Ogasawara*. Peroxidatic cysteine residue of peroxiredoxin 2 separated from human red blood cells treated by tert-butyl hydroperoxide is hyperoxidized into sulfinic and sulfonic acids. Human Cell, Epub ahead of print. *; Co-corresponding author

研究業績9

Yo-ichi Ishida, Tasuku Kayama, Yosuke Kibune, Shoichi Nishimoto, Shin Koike, Toshihiro Suzuki, Yasue Horiuchi, Mitsuhiro Miyashita, Masanari Itokawa, Makoto Arai, Yuki Ogasawara. Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients: a possible biomarker for diseases involving carbonyl stress. Biochemical and Biophysical Research Communications, Epub ahead of print.

研究業績10

Nobuhiro Hiraishi*, Yo-ichi Ishida*, Haruka Sudo, Masami Nagahama. WDR74 participates in an early cleavage of the pre-rRNA processing pathway in cooperation with the nucleolar AAA-ATPase NVL2. Biochemical and Biophysical Research Communications, in press. *; Co-first authors

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