Organic and Medicinal Chemistry
Tomomi KAWASAKI, Ph.D., Professor
Kazuhiro HIGUCHI, Ph.D., Lecturer
Masahiro TAYU, M.Pharm., Research Associate
Research in our laboratory is directed towards the synthesis of bioactive natural compounds, design and synthesis of peptidomimetics of biologically important peptides, and development of efficient synthesizing methods to support this.
1.Total Synthesis: Efforts are currently under way in our laboratory towards the total synthesis of indole and piperazine alkaloids and analogues aimed at delaying the progression of Alzheimer'disease, anti-fungal activity and anti-tumor activity.
2.New Reactions and Synthetic Methods: In order to facilitate the synthesis of biologically active compounds, we are developing new and efficient strategies in synthetic chemistry using domino reactions, pericyclic reactions (Claisen and Cope rearrangement), abnormal Pummerer reactions and transamidation-cyclization.
3.Non-protein Amino Acids: We are examining the preparation of arylglycines as non-protein amino acids, and developing the synthesis of bioactive peptides and non-peptides.
4.Peptide-Mimetic: Research is underway in our laboratory directed towards the design, synthesis, and study of small non-peptide molecules mimicking the β-turn structure of biologically important peptides.