Clinical Pharmaceutics
Kiminori MOHRI, Ph.D., Professor
Yoshihiro UESAWA, Ph.D., Assistant Professor
Reiko NOZAWA, Ph.D.,Research Associate
The purpose of our research is possible clinically-applicable studies based on pharmaceutics and pharmacokinetics. It is important to know the relationship between the living body and a drug to bring out the maximum pharmacological action and to keep the adverse effect to a minimum. Currently we are focusing on the characteristics of drug metabolism enzymes and the interaction of drugs and foods.
1. Study of stereoselective pharmacokinetics and metabolism of racemic compounds: It is known that each R- and S-isomer of racemic compounds shows different pharmacological and pharmacokinetic profiles. We are interested in stereoselective amino acid conjugation and glucuronidation against each enantiomer of racemic compounds.
2. Study of UDP-glucuronyltransferases on N-glucuronidation: We are investigating the biochemical properties of UDP-glucuronosyltransferases that make the glucuronic acid conjugation at the N-atom of dulcin and bucolome
3. Study of the effect of grapefruit juice co-ingestion on the pharmacokinetics of nifedipine: It is known that grapefruit juice produces a pharmacokinetic interaction with many drugs when they are taken together. There is a possibility that the drug concentrations increase significantly, which may cause serious adverse reactions. We are studying the effect of grapefruit juice on the pharmacokinetics of nifedipine after drug co-administration.
