Drug Metabolism and Disposition
Hisahiro YOSHIDA, Ph.D., Professor
Yoji IKEGAMI, Ph.D., Associate Professor
Kazumi SANO, B.Pharm., Lecturer
Our main theme of study is "Clarification of drug transport-mechanisms through various organ cell lines, and establishment of rational drug therapeutics reflected individual properties." To pursue this theme, we are conducting the following studies:
1. Study of the transport and metabolism of various drugs in renal and intestinal cell lines
2. Study of the aspirin tolerance mechanism and establishment of rational anti-platelet therapy
3. Establishment of adjuvant therapy to support a regenerative medicine and a cancer therapy
4. Study of the drug interaction between new quinolone antibiotics and Chinese medicine
5. Development of new anticancer drugs targeting resistant molecules
6. Effect of the ABCG2 inhibitor on the therapeutic effect of anticancer drug CPT-11
7. Study of the relationship between the genetic polymorphism of ABCG2 and the anticancer resistance
8. Effect of gefitinib on CPT-11 transport by breast cancer resistance protein (BCRP) as an ATP-dependent efflux pump
9. Quantitation of gefitinib and its metabolites in patients’ plasma using HPLC and LC-MS
10. Study of factors influencing blood concentrations of midazolam
