明治薬科大学 分析化学研究室
明治薬科大学 分析化学研究室

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研究内容


最近5年間の研究室の業績



原著論文

2017年

1. Shimura S, Watashi K, Fukano K, Peel M, Sluder A, Kawai F, Iwamoto M, Tsukuda S, Takeuchi JS, Miyake T, Sugiyama M, Ogasawara Y, Park SY, Tanaka Y, Kusuhara H, Mizokami M, Sureau C, Wakita T.
Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity. J Hepatol. 66, 685-692 (2017)

2. Hanaoka K, Sasakura K, Suwanai Y, Toma-Fukai S, Shimamoto K, Takano Y, Shibuya N, Terai T, Komatsu T, Ueno T, Ogasawara Y, Tsuchiya Y, Watanabe Y, Kimura H, Wang C, Uchiyama M, Kojima H, Okabe T, Urano Y, Shimizu T, Nagano T.
Discovery and Mechanistic Characterization of Selective Inhibitors of H2S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide. Sci Rep. 7, 40227 (2017)

3. Miyamoto R, Koike S, Takano Y, Shibuya N, Kimura Y, Hanaoka K, Urano Y, Ogasawara Y, Kimura H.
Polysulfides (H2Sn) produced from the interaction of hydrogen sulfide (H2S) and nitric oxide (NO) activate TRPA1 channels. Sci Rep. 7, 45995 (2017)

4. Nishimoto S, Koike S, Inoue N, Suzuki T, Ogasawara Y.
Activation of Nrf2 attenuates carbonyl stress induced by methylglyoxal in human neuroblastoma cells: Increase in GSH levels is a critical event for the detoxification mechanism. Biochem Biophys Res Commun. 483, 874-879 (2017)

5. Koike S, Nishimoto S, Ogasawara Y.
Cysteine persulfides and polysulfides produced by exchange reactions with H2S protect SH-SY5Y cells from methylglyoxal-induced toxicity through Nrf2 activation. Redox Biol. 12, 530-539 (2017)

6. Ishida YI, Aki M, Fujiwara S, Nagahama M, Ogasawara Y.
Peroxidatic cysteine residue of peroxiredoxin 2 separated from human red blood cells treated by tert-butyl hydroperoxide is hyperoxidized into sulfinic and sulfonic acids.
Hum Cell. (2017)

7. Ikeda R, Ogasawara Y, Takatori K, Ichikawa T, Nakajima M, Harigaya K, Watanabe M, Okudaira E, Yoshikawa H, Yanagisawa K.
Growth Inhibition of an Opportunistic Yeast Pathogen Trichosporon asahii by Staphylococcus epidermidis. Biol Pharm Bull. 40, 693-697 (2017)

8. Fujihara K, Koike S, Ogasawara Y, Takahashi K, Koyama K, Kinoshita K.
Inhibition of amyloid β aggregation and protective effect on SH-SY5Y cells by triterpenoid saponins from the cactus Polaskia chichipe. Bioorg Med Chem. 25, 3377-3383 (2017)

9. Kimura Y, Koike S, Shibuya N, Lefer D, Ogasawara Y, Kimura H.
3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S. Sci Rep. 7, 10459 (2017)

10. Ishida Y.I, Kayama T, Kibune Y, Nishimoto S, Koike S, Suzuki T, Horiuchi Y, Miyashita M, Itokawa M, Arai M, Ogasawara Y.
Identification of an argpyrimidine-modified protein in human red blood cells from schizophrenic patients: A possible biomarker for diseases involving carbonyl stress. (2017) in press

 

2016年

1. Ogasawara Y, Tanaka R, Koike S, Horiuchi Y, Miyashita M, Arai M.
Determination of methylglyoxal in human blood plasma using fluorescence high performance liquid chromatography after derivatization with 1,2-diamino-4,5-methylenedioxybenzene. J Chromatogr B Analyt Technol Biomed Life Sci. 1029-1030, 102-105 (2016)

2. Koike S, Kayama T, Yamamoto S, Komine D, Tanaka R, Nishimoto S, Suzuki T, Kishida A, Ogasawara Y.
Polysulfides protect SH-SY5Y cells from methylglyoxal-induced toxicity by suppressing protein carbonylation: A possible physiological scavenger for carbonyl stress in the brain. Neurotoxicology. 55, 13-19 (2016)

3. Koike S, Tanaka Y, Matsuzaki T, Morishita Y, Ishibashi K.
Aquaporin-11 (AQP11) Expression in the Mouse Brain. Int. J. Mol. Sci. 17, 861 (2016)

4. Nishimoto S, Suzuki T, Koike S, Yuan B, Takagi N, Ogasawara Y.
Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells. Toxicol Appl Pharmacol. 305, 161-168 (2016)

5. Yokoya M, Toyoshima M, Suzuki T, Le V. H, Williams R. M and Saito N
Stereoselective Tota Synthesis of (-)-Renieramycin T. J. Org. Chem. 81, 4039-4047 (2016)

6. Toyoshima R, Mori N, Suzuki T, Lowtangkitcharoen W, Suwanborirux K, Saito N.
Chemisty of Ecteinascidins. Part 5. An Additional Proof of Cytotoxicity Evaluation of Ecteinascidin 770 Derivatives. Chem. Pharm. Bull, 64, 966-969 (2016)

 

2015年

1. Ogasawara Y, Ishida Y, Takikawa M, Funaki Y, Suzuki T, Koike S.
A simple high performance liquid chromatography method for quantitatively determining the reduced form of peroxiredoxin 2 and the mass spectrometric analysis of its oxidative status. J Chromatogr B Analyt Technol Biomed Life Sci. 997, 136-141 (2015)

2. Koike S, Shibuya N, Kimura H, Ishii K, Ogasawara Y.
Polysulfide promotes neuroblastoma cell differentiation by accelerating calcium influx. Biochem Biophys Res Commun. 459, 488-492 (2015)

3. Kimura Y, Toyofuku Y, Koike S, Shibuya N, Nagahara N, Lefer D, Ogasawara Y, Kimura H.
Identification of H2S3 and H2S produced by 3-mercaptopyruvate sulfurtransferase in the brain. Sci Rep. 5, 14774 (2015)

4. Koike S, Kayama T, Arai M, Horiuchi Y, Kobori A, Miyashita M, Itokawa M, Ogasawara Y.
Characterization of modified proteins in plasma from a subtype of schizophrenia based on carbonyl stress: Protein carbonyl is a possible biomarker of psychiatric disorders. Biochem Biophys Res Commun. 467, 361-366 (2015)

5. Suzuki T, Ishibashi K, Yumoto A, Nishio K, Ogasawara Y.
A possible utilization of arsenic trioxide against cisplatin-resistant non-small cell lung cancer. Oncology letters 10, 805-809 (2015)

 

2014年

1. Ogasawara Y, Takeda Y, Takayama H, Nishimoto S, Ichikawa K, Ueki M, Suzuki T, Ishii K
Significance of the rapid increase in GSH levels in the protective response to cadmium exposure through phosphorylated Nrf2 signaling in Jurkat T-cells. Free Radic. Biol. Med. 69, 58-66 (2014)

2. Nagasawa I, Kaneko A, Suzuki T, Nishio K, Kinoshita K, Shiro M, Koyama K. Potential anti-angiogenesis effects of p-terphenyl compounds from Polyozellus multiplex. Journal of natural products 77, 963-968 (2014)

3. Ogasawara Y, Imase M, Oda H, Wakabayashi H, Ishii K.
Lactoferrin directly scavenges hydroxyl radicals and undergoes oxidative self-degradation: a possible role in protection against oxidative DNA damage. Int. J. Mol. Sci. 15, 1003 (2014)

4. Ishida YI, Takikawa M, Suzuki T, Nagahama M, Ogasawara Y.
Irreversible hyperoxidation of peroxiredoxin 2 is caused by tert-butyl hydroperoxide in human red blood cells. FEBS Open Bio. 4, 848 (2014)

 

2013年

1. Shibuya N, Koike S, Tanaka M, Ishigami-Yuasa M, Kimura Y, Ogasawara Y, Fukui K, Nagahara N, Kimura H.
A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells. Nature Commun. 4, 1366 (2013)

2. Ogasawara Y, Hirokawa T, Matsushima, Koike S, Shibuya N, Tanabe S, Ishii K.
A novel method for the analysis of 3-mercaptopyruvate using high-performance liquid chromatography with fluorescence detection. J. Chromatgr.,Bioanalyte B, 931, 56-60 (2013)

3. Koike S, Ogasawara Y, Shibuya N, Kimura H, Ishii K.
Polysulfide exerts a protective effect against cytotoxicity caused by t-buthylhydroperoxide through Nrf2 signaling in neuroblastoma cells. FEBS Lett. 587, 3548-3555 (2013)

4. Mikami Y, Shibuya N, Ogasawara Y, Kimura H.
Hydrogen sulfide is produced by cystathionine γ-lyase at the steady-state low intracellular Ca2+ concentrations. Biochem. Biophys. Res. Commun. 431 131-135 (2013)

5. Pouliot L. M, Shen D. W, Suzuki T, Hall M. D, Gottesman, M. M.
Contributions of microRNA dysregulation to cisplatin resistance in adenocarcinoma cells. Experimental cell research 319, 566-574 (2013)

 

2012年

1. Ogasawara Y, Ohminato T, Nakamura Y, Ishii K.
Structural and functional analysis of native peroxiredoxin 2 in human red blood cells. Int. J. Biochem. Cell Biol. 44,1072-1077 (2012)

2. Uemura M, Suzuki T, Nishio K, Chikum M, Komeda S.
An in vivo highly antitumor-active tetrazolato-bridged dinuclear platinum(II) complex largely circumvents in vitro cisplatin resistance: two linkage isomers yield the same product upon reaction with 9-ethylguanine but exhibit different cytotoxic profiles. Metallomics : integrated biometal science 4, 686-692 (2012)

 


 

総 説

  1. 酸化ストレスマーカーの予防医学における実用性:小笠原裕樹、ぶんせき、18-23 (2008)
  2. 生体内でシステインから産生される硫化水素と結合型イオウの生理的な役割: 小池伸、小笠原裕樹、硫酸と工業, 69, 167-178 (2016)
  3. Sulfur Atom in its Bound State Is a Unique Element Involved in Physiological Functions in Mammals. Koike S, Ogasawara Y. Molecules, 21, 1753 (2016)





明治薬科大学 分析化学研究室
〒204-8588 東京都清瀬市野塩2-522-1
TEL 042-495-8931